洞察前沿，连接科研新知

完整作者

Yu Luo、Chenfei Meng、Lu Wang、Bo Liang

作者机构

• Energy-Rich Compounds Production by Photosynthetic Carbon Fixation Research Center, Shandong Key Lab of Applied Mycology, College of Life Sciences, Qingdao Agricultural University, Qingdao, China.
• Energy-Rich Compounds Production by Photosynthetic Carbon Fixation Research Center, Shandong Key Lab of Applied Mycology, College of Life Sciences, Qingdao Agricultural University, Qingdao, China. liangbo@qau.edu.cn.

技术路线

暂未整理

最近 5 个完整年度引用趋势

完整作者

Hongzhong Lu、Zhendong Zhang、Siwei He、Yucan Zhang、Yuguang Wang、Fei Tao、Jens Nielsen

作者机构

• State Key Laboratory of Microbial Metabolism, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
• Institute of Natural Sciences, School of Mathematical Sciences, Zhangjiang Institute of Advanced Study, Shanghai Jiao Tong University, Shanghai 200240, China.
• Shanghai AI Laboratory, Shanghai 200232, China.
• BioInnovation Institute, Ole Måløes Vej, Copenhagen N DK2200, Denmark.
• Department of Life Sciences, Chalmers University of Technology, Gothenburg SE412 96, Sweden.

技术路线

暂未整理

最近 5 个完整年度引用趋势

完整作者

Fan Wei、Xiaogui Deng、Haoran Li、Ruoyu Wang、Zhitao Mao、Yufeng Mao、Yushuo Liu、Qishun Niu、Yuxin Qin、Jun Du、Xiaoping Liao、Yu Bai、Qianqian Yuan、Hongwu Ma

作者机构

• Biodesign Center, Key Laboratory of Engineering Biology for Low-carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
• Haihe Laboratory of Synthetic Biology, Tianjin 300308, China.
• National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China.
• College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China.

技术路线

数据/样本：整合74,237种食品相关化合物（标准化化学身份及食品出现、生物活性、毒性、监管注释），专家审编1,054种化合物的生物制造证据（来自5,592篇文献，关联微生物宿主、底物、遗传修饰及定量生产指标），并收录971种化合物的2,002条文献报道生物合成途径。分析：构建化合物-生物制造证据-生物合成途径的结构化可溯源知识库；对无文献途径的化合物进行计算预测候选途径。验证：原文未报告实验验证。

最近 5 个完整年度引用趋势

完整作者

Yang Lan、Xuemin Liu、Zhifeng Shi、Yuanlong Li、Ani Chi、Jiaqian Zheng、Tan Ye、Chuang Xiao、Rui Zheng、Yifan Yang、Xuetao Shi、Xufeng Zhu、Muyuan Chai、Shengtao Yan

作者机构

• National Engineering Research Centre For Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, P. R. China.
• School of Materials Science and Engineering, South China University of Technology, Guangzhou, P. R. China.
• Guangdong Provincial Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, P. R. China.
• Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, P. R. China.
• Medical Devices Research & Testing Center, South China University of Technology, Guangzhou, P. R. China.
• Orthopedics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, P. R. China.
• School of Ocean and Tropical Medicine, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, P. R. China.
• Department of Emergency, China-Japan Friendship Hospital, Beijing, P. R. China.

技术路线

数据/样本：工程化活体载具（ELV）基于大肠杆菌Nissl 1917底盘，表面修饰(DSS)6肽；体外及MRSA诱导的大鼠骨髓炎模型。分析：层级整合环境生物传感器与逻辑门计算模块，利用AlphaFold 3引导分子对接设计多尺度热响应遗传逻辑电路，实现≥37°C生产LYS和VIP、≥42°C热自毁。验证：在大鼠骨髓炎模型中静脉注射ELV，评估自主导航、生物膜穿透、病原清除（与万古霉素比较）及骨修复效果。

最近 5 个完整年度引用趋势

完整作者

Tanja Hann、Harim Jang、Yu-Chieh Sung、Chia-Lun Guh、Nicholas M Hiers、Lucille H Tsao、Michelle Luo、Anna Marie Pyle

作者机构

• Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
• Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
• Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.
• Department of Chemistry, Yale University, New Haven, CT, USA.
• Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Department of Chemistry, Yale University, New Haven, CT, USA. Electronic address: anna.pyle@yale.edu.

技术路线

综述性文章，未报告原始数据/样本；基于已有文献整合分析与跨病毒家族比较，无独立实验验证

最近 5 个完整年度引用趋势

完整作者

Dujuan Liu、Chuang Yan、Jiangfeng Fu、Zili Liao、Youcheng Zhang、Haiyun Gan、Haokui Zhou、Xian-En Zhang、Minghai Chen

作者机构

• State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; School of Life Sciences, Henan University, Kaifeng, China.
• State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
• Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen, China; State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China. Electronic address: zhangxe@ibp.ac.cn.
• State Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Faculty of Synthetic Biology, Shenzhen University of Advanced Technology, Shenzhen, China. Electronic address: mh.chen1@siat.ac.cn.

技术路线

['数据/样本：SARS-CoV-2 N蛋白与宿主细胞蛋白的相互作用体系；通过NIR-BiFC-Seq高通量鉴定互作组', '分析：筛选N蛋白与宿主蛋白互作，鉴定LSD1；分析LSD1对N蛋白K233位点的去甲基化作用及其对N蛋白二聚化、与Nsp12互作、病毒RNA结合和液-液相分离的影响', '验证：使用靶向K233位点的抑制剂检测对SARS-CoV-2产量的抑制效果']

最近 5 个完整年度引用趋势

完整作者

Juergen Fieder、Stefan Schneider、Simon Fischer

作者机构

• Cell Line Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
• University of Applied Sciences Biberach, Biberach, Germany.

技术路线

文献/历史资料 → 按年代梳理CHO细胞系开发进程

最近 5 个完整年度引用趋势

完整作者

Butaek Lim、Tekle Fida、Karen Crippen、Rebekah Wilson、Seung-Wuk Lee

作者机构

• Department of Bioengineering, University of California, Berkeley, CA 94720, USA.
• Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA.
• Gas Technology Institute, 1700 South Mount Prospect Rd, Des Plaines, IL 60018, USA.
• US Army Corps of Engineers, Champaign, IL 61820, USA.

技术路线

暂未整理

最近 5 个完整年度引用趋势

完整作者

Letong Huang、Hongqin Sun、Yi Huang、Qingyi Gu、Hailong Zhang、Dingqin He、Wenyi Zhang、Siyu Chen、Delin Xu、Juanjuan Zhao

作者机构

• Department of Medical Instrumental Analysis, Zunyi Medical University, Zunyi 563000, China.
• Key Laboratory of Cancer Prevention and Treatment of Guizhou Province, Zunyi 563000, China.
• Department of Clinical Medicine, Nantong University, Nantong 226019, China.
• Special Key Laboratory of Oral Disease Research and High Education Institute in Guizhou Province, School of Stomatology, Zunyi Medical University, Zunyi 563000, China.

技术路线

暂未整理

最近 5 个完整年度引用趋势

完整作者

Ziqian Lin、Han Huang、Jiuming Wang、Liang Hong、Irwin King、Yu Li

作者机构

• Department of Computer Science and Engineering, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR 999077, China.
• Department of Computer Science and Engineering, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR 999077, China. Electronic address: liyu@cse.cuhk.edu.hk.

技术路线

结构数据（由AI辅助实验方法持续扩展）→ AI模型利用三级结构解读功能并指导序列生成

最近 5 个完整年度引用趋势