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公共数据库临床研究Neurology

Proximity to Water Pollutant Facilities and Risk of Incident Progressive Supranuclear Palsy: Nested Case-Control Study of the UK Biobank.

暂无引用数据

英国生物银行前瞻性队列嵌套病例对照研究比较221例新发进行性核上性麻痹(PSP)患者(平均年龄63.0岁,女性41.2%)与2249名年龄、性别匹配对照,依据基线住址与欧洲污染物释放和转移登记册所列设施的距离评估暴露。经错误发现率校正后,住址靠近排放重金属(OR 1.38,95%CI 1.03–1.85)、农药(OR 1.66,95%CI 1.12–2.46)、其他有机污染物(OR 1.52,95%CI 1.13–2.04)及其他无机污染物(OR 1.60,95%CI 1.19–2.15)的设施与新发PSP风险升高相关;风险随距离增大(5–10 km)呈线性下降,居住超过40年者重金属及有机、无机污染物相关风险升高,较短居住时间未见此关联。结论认为,住宅邻近排放水污染物的设施与新发PSP相关,可能存在距离依赖和持续时间依赖关系,提示环境水污染物或参与PSP发病。

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完整作者

Charlie Weige Zhao、Christopher D Stephen、Marian L Dale、Alexander Pantelyat、Maria Carmela Tartaglia、Ruth B Schneider、David G Coughlin、Federico Rodriguez-Porcel、Tao Xie、Burton Scott、Douglas Gunzler、Lawrence I Golbe、James B Rowe、Irene Litvan、Zoltan Mari、Anne-Marie A Wills

作者机构

  • Department of Neurology, Mass General Brigham, Boston, MA.
  • Harvard Medical School, Boston, MA.
  • Department of Neurology, Oregon Health and Science University, Portland.
  • Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada.
  • Memory Cinic, University Health Network, Toronto, Ontario, Canada.
  • Department of Neurology and Center for Health & Technology, University of Rochester, NY.
  • Department of Neurosciences, University of California San Diego.
  • Department of Neurology, Medical University of South Carolina, Charleston.
  • Department of Neurology, University of Chicago Medicine, IL.
  • Duke University, Durham, NC.
  • Case Western Reserve University, Cleveland, OH.
  • MetroHealth System, Cleveland, OH.
  • Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
  • CurePSP Inc., New York, NY.
  • Department of Clinical Neurosciences, MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom.
  • Cambridge University Hospitals NHS Trust, University of Cambridge, United Kingdom; and.
  • Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV.

技术路线

UK Biobank前瞻性队列嵌套病例对照(221例 incident PSP 与2249例年龄性别匹配对照) → 按基线居住地与欧洲PRTR水体污染物排放设施邻近度分组

最近 5 个完整年度引用趋势

暂无引用数据

数据来源:暂未标注更新时间:暂无更新时间

实际检索式

Proximity OR Water OR Pollutant OR Facilities OR Risk OR UK Biobank OR rare disease OR risk model数据更新时间:2026/11/02 05:37

相关研究数量

数量受检索式影响
0894217883159522021168662022163152023164352024178832025

仅展示最近 5 个完整年度,不包含 2026 年 YTD。

2026 年 · YTD15006

年初至今数量单独展示,不与完整年度直接比较。

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Residential proximity to PRTR water-pollutant facilities and incident atypical parkinsonism: a competing-risk and dose-response reanalysis in UK Biobank

研究问题
Is residential proximity to PRTR water-pollutant-emitting facilities associated with incident atypical parkinsonian syndromes (PSP, MSA, CBS) as a composite outcome, and does the association differ by pollutant class and residence duration under competing-risk framing?
暴露 / 干预
Baseline residential proximity (distance bands and inverse-distance metrics) to European PRTR facilities reporting releases to water, stratified by pollutant class (heavy metals, pesticides, organic, inorganic)
研究结局
Incident atypical parkinsonism (PSP, multiple system atrophy, corticobasal syndrome) identified from linked hospital/death records, with all-cause death as competing risk
数据来源
UK Biobank cohort linked to Hospital Episode Statistics and death registrations; European PRTR 2007 facility inventory
研究设计
Prospective cohort with nested case-control augmentation; competing-risk Cox models and distance-response splines
推荐理由
The original nested case-control study (221 PSP cases) reported ORs of 1.38-1.66 for pollutant classes with distance- and duration-dependence, but the small case count limits precision and class-specific inference. Real similar work in the same PRTR-proximity paradigm exists for mammographic density (DDM-Madrid) and for air pollution distance-decay around oil/gas facilities, indicating the exposure-assessment approach is established but not disease-specific to PSP. Inference boundary: expanding to atypical parkinsonism is a hypothesis-generating extension, not evidence of shared etiology.
创新点说明
Shifts from single-disease PSP case-control to a competing-risk multi-syndrome outcome with formal dose-response modeling; does not claim an unexplored exposure-disease link, only methodological and outcome-breadth extension.
风险提示
Outcome misclassification for MSA/CBS is substantial in routine records; competing-risk models may still be underpowered given rare outcomes; PRTR 2007 snapshot misses residential mobility and later facility changes; residual confounding by urbanicity, socioeconomic status, and smoking.

Duration-weighted residential exposure to water-pollutant facilities and PSP: testing a cumulative exposure metric with residential-history reconstruction

研究问题
Does a cumulative, duration-weighted residential exposure metric (facility proximity × years of residence) outperform baseline single-timepoint proximity in predicting incident PSP?
暴露 / 干预
Cumulative residential exposure score integrating PRTR facility proximity with reconstructed residential histories and residence duration windows
研究结局
Incident progressive supranuclear palsy diagnosis
数据来源
UK Biobank baseline and follow-up residential address records; PRTR facility inventory; linked HES and death records
研究设计
Nested case-control with exposure misclassification simulation; comparison of baseline-only vs duration-weighted metrics via AUC, AIC, and quantitative bias analysis
推荐理由
The original study found that residence exceeding 40 years conferred increased risk for heavy metals and organic/inorganic pollutants, unlike shorter windows, suggesting duration matters. However, baseline-only proximity cannot distinguish cumulative from current exposure. Real literature on PRTR proximity and health (mammographic density study) similarly relies on cross-sectional proximity, highlighting a general measurement limitation. Inference boundary: the hypothesis that duration-weighting improves prediction is plausible but untested; the original duration finding could reflect age or survival effects rather than cumulative dose.
创新点说明
Focuses on exposure-metric validation and quantitative bias analysis rather than a new disease association; explicitly tests whether the duration-dependent signal in the original paper survives formal cumulative-exposure modeling.
风险提示
UK Biobank residential history is incomplete and self-reported at baseline; residential mobility can induce exposure misclassification; 40-year residence is strongly correlated with age and regional deprivation; simulation-based bias correction rests on untestable assumptions.

Water-pollutant facility proximity and PSP: effect modification by genetic susceptibility and agricultural co-exposure

研究问题
Does the association between PRTR water-pollutant facility proximity and incident PSP differ by genetic risk variants (e.g., MAPT H1/H2 haplotype, LRRK2) or by co-exposure to agricultural pesticide application?
暴露 / 干预
PRTR facility proximity (pollutant-class specific) crossed with genetic risk strata and with spatially modeled agricultural pesticide exposure
研究结局
Incident progressive supranuclear palsy diagnosis
数据来源
UK Biobank genetic data (MAPT, LRRK2), PRTR facility inventory, agricultural census/land-use pesticide data, linked HES and death records
研究设计
Nested case-control with gene-environment interaction and multi-exposure interaction analyses; stratified and multiplicative/additive interaction models
推荐理由
The original paper reports pesticide-emitting facility proximity OR 1.66 and organic/inorganic pollutant associations, but does not examine genetic susceptibility or agricultural co-exposure. Real similar work includes PRTR proximity and mammographic density showing pollutant-specific associations, and air pollution distance-decay work around oil/gas facilities, supporting the plausibility of pollutant-class heterogeneity. Inference boundary: interaction analyses with ~221 cases are exploratory and will be severely underpowered; any signal would require replication.
创新点说明
Adds gene-environment and multi-source exposure interaction dimensions to the original exposure-outcome question; does not assert a novel environmental cause, but tests whether the observed association is concentrated in susceptible subgroups.
风险提示
Very low power for interaction terms with rare outcome; MAPT genotype missing or imputed for many participants; agricultural pesticide exposure models are spatially coarse and correlated with facility proximity; multiple testing burden high; additive interaction estimates unstable.

Comparative analysis of PRTR water versus air pollutant facility proximity and PSP: assessing exposure-route specificity

研究问题
Is the PSP association stronger for facilities reporting releases to water compared with facilities reporting only to air, and does the pattern support a waterborne versus airborne exposure route?
暴露 / 干预
Facility proximity classified by reported environmental release route (water-only, air-only, both) from PRTR
研究结局
Incident progressive supranuclear palsy diagnosis
数据来源
European PRTR facility inventory (release-route fields); UK Biobank residential proximity; linked HES and death records
研究设计
Nested case-control with mutually adjusted release-route exposure categories; negative-control outcome analysis to assess confounding
推荐理由
The original study restricted exposure to water pollutant-emitting facilities and interpreted findings as supporting a waterborne route, but did not compare air-only facilities. Real similar work includes distance-decay gradients for air pollution around oil/gas facilities and PRTR proximity studies covering multiple industrial sectors, showing that route-specific contrasts are feasible with PRTR data. Inference boundary: facilities often report to both media, and proximity cannot separate inhalation from ingestion; route-specific inference is indirect and susceptible to co-reporting.
创新点说明
Directly interrogates the exposure-route interpretation of the original paper by contrasting water-only, air-only, and dual-release facilities; a falsification-oriented design rather than a new association claim.
风险提示
PRTR release-route reporting is incomplete and inconsistent across countries; water-only facilities are relatively few, reducing power; air and water facility locations overlap spatially, causing collinearity; negative-control outcomes may be unavailable in UK Biobank at sufficient frequency.

相似文献

10 篇

Proximity resonances of water-entrained air bubbles near acoustically reflecting boundaries.

The Journal of the Acoustical Society of America · 2021
Elwin van 't Wout、Christopher Feuillade

The acoustic resonances of radiatively damped air bubbles in water near reflecting boundaries are investigated by representing the bubble and its image by two bubbles in a full space, ensonified by two incident fields. Results obtained using an analytic monopole theory are compared with those of a coupled spherical harmonic technique and a boundary element method. Near a rigid boundary, the resonance frequency is reduced, and the response characteristics are determined by the predominant monopolar character of the individual bubble motion, with small changes in peak amplitude and Q. Near a sound-soft boundary, a higher frequency proximity resonance is observed. The monopole field is cancelled out, and the response is determined by higher-order scattering modes, giving very high values of Q. While the individual bubble scattering level increases significantly, the overall scattering is less than for two uncoupled bubbles. For bubble separations of 8-28 radii, all three approaches predict essentially identical results for both boundary types. For bubble separations less than one radius, the monopole theory, which does not include higher-order scattering modes, diverges from the boundary element and coupled spherical harmonic methods, whose high-accuracy determinations of resonance frequencies and amplitudes agree to within 0.1%.

Designing for Embodied Proximity.

Visitor studies. Visitor Studies Conference · 2024
Minna O Nygren、Rhiannon Thomas Jha、Sara Price

This paper draws on notions of embodied learning to inform exhibit design that fosters children's meaningful embodied engagement to successfully unveil science ideas. While children's interaction in the museum is often hands-on and speaks to the physical emphasis that embodiment brings, observation of children's spontaneous engagement at a museum's Water Zone revealed opportunities and barriers to engagement with, and access to, science ideas in terms of what we call 'embodied proximity' and 'embodied dislocation'. Drawing on design considerations from these findings a set of purpose-built prototype exhibits were developed and deployed to examine how they supported children's embodied exploration of science. The findings highlight key design dimensions that support children's accessing and making meaning about science through fostering embodied proximity: considering palette of embodied features; applying direct multisensorial experience; developing temporal-positional contiguity; and designing opportunities for communicating experiences through the body.

Natural and Built Environments and Heart Failure Risk: An Exposome-Wide Analysis in the UK Biobank.

Environmental Research · 2025
Xue-Wei Huang、Siyu Yin、Meng Yao 等

Natural and built environments are closely linked to cardiovascular health, yet the environmental determinants of heart failure (HF) risk remain poorly understood. In a prospective cohort of 377,694 UK Biobank participants without HF at baseline, we analyzed the associations between 241 environmental exposures and the risk of incident HF using an exposome-wide approach. Our analysis included exposome-wide association study (ExWAS) analyses via Cox regression, identification of key exposures using regularized Cox regression and LightGBM models, and pattern recognition with self-organizing maps and k-means clustering to assess cumulative effects. After adjusting for confounders and multiple testing, 54 exposures were significantly associated with HF risk in the ExWAS. Combining results from the regularization model and LightGBM, we identified protective factors like greater natural space and lower air pollution, and risk factors such as proximity to industrial facilities and high traffic density. Seven environmental patterns were identified, with the lowest HF risk linked to high natural environments and robust infrastructure. BMI was found to mediate these environmental links to HF. Our findings demonstrate that natural and built environments are strongly associated with HF risk, and targeted strategies to reduce environmental pollution and optimize community design may offer promising ways for mitigating HF burden.

Proximity-induced FRET and charge-transfer between quantum dots and curcumin enable reversible thermochromic hybrid polymeric films.

Chemical communications (Cambridge, England) · 2024
Jefin Parukoor Thomas、R B Amal Raj、G Virat 等

This study introduces a novel strategy for developing reversible thermochromic fluorescent films by precisely controlling the nanoscale proximity of boron nitride quantum dots and curcumin molecules within a poly(3-hydroxybutyrate) matrix. The synergistic interaction and Förster resonance energy transfer between these fluorophores result in an energy transfer efficiency of ∼94%. This approach enables tunable color changes in response to temperature variations, governed by the segmental mobility of polymer chains. Practical applications of these films as temperature sensors for water bottles and electronic devices are demonstrated, highlighting their potential in temperature monitoring, smart packaging, and thermal management systems.

Distance decay gradients in hazardous air pollution concentrations around oil and natural gas facilities in the city of Los Angeles: A pilot study.

Environmental research · 2019
Diane A Garcia-Gonzales、Bhavna Shamasunder、Michael Jerrett

In this work, we investigate air pollutant distance decay gradients around an upstream oil and natural gas (ONG) facility located within a densely populated urban community in South Los Angeles. Despite the difficulties associated with interpreting air quality measurements in complex, multi-source urban environments, this pilot investigation was able to identify distance decay around the target ONG site and distinguish added air quality burden of several volatile organic compounds associated with ONG operations. Moving forward, we recommend additional research to better distinguish air quality contributions from ONG in urban environments.

Urban park features and cardiovascular disease: a prospective analysis of 377,817 UK biobank participants.

Environment International · 2025
Fiona M Caryl、J. Olsen、T. Astell-Burt 等

BACKGROUND Greenspace benefits for cardiovascular disease (CVD) may depend more on quality than proximity, but feature-specific evidence is limited. METHODS We linked objectively mapped park features to 377,817 urban UK Biobank participants and followed incident CVD (46,474 events) over a median 14.1 years. Network-based walk-distance catchments (400/800/1,600 m) were delineated for each home. We created an "any park" present indicator and feature-specific park indicators (e.g. tree canopy, water, cafes, toilets, attractions, sports) at each distance. Cox proportional hazards mixed-effects models adjusted for sociodemographic covariates, area deprivation, ambient natural landcover, and geographical clustering. Effect modification by sex, area-level deprivation, and age group (<65/≥65) was examined. RESULTS "Any park" was not associated with CVD, whereas feature-specific models indicated modest protection (≈3-6 % lower hazards). Tree canopy showed the strongest, distance-stable pattern with clearest support for ≥50 % at 800 m (HR 0.941, 95 % CI 0.912-0.992). Water features were protective at 400 m (HR 0.946, 95 % CI 0.907-0.986). Cafes were protective at 800 m (HR 0.971, 95 % CI 0.945-0.999), and 2+ public attractions at 1,600 m (HR 0.977, 95 % CI 0.957-0.997). Sports facilities at 800 m were associated with higher risk (HR 1.028, 95 % CI 1.004-1.057). Effect modification was limited: cafes at 800 m were more protective in high-deprivation areas; ≥50 % canopy at 1,600 m were more protective in women. CONCLUSIONS What's inside parks matters more than proximity. Higher tree canopy and nearby blue features appear broadly protective, while strategically placed amenities may support engagement.

Microbial population structure: Forced proximity is shaped by capillary interactions.

Current biology : CB · 2025
Miles Wetherington、Peter J Yunker

A recent study shows that the spatial organization of bacteria in thin films or near air-water interfaces is strongly impacted by a purely physical mechanism - capillary interactions. This mechanism likely plays an important role in bacterial assortment in environments like soil, which undergo wet and dry cycles, thus changing the water level over time.

Neighbourhood built environments, socioeconomic position, and hospital admissions for cardiovascular disease: a prospective study using UK Biobank

medRxiv · 2023
K. Mason、N. Pearce、S. Cummins

Background: Neighbourhood environments may influence cardiovascular disease (CVD) risk, e.g. by influencing diet and physical activity (PA) behaviours. We explored whether associations between characteristics of neighbourhood environments and CVD are modified by area deprivation and household income. If effects of neighbourhood risk exposures vary by socioeconomic position, efforts to improve population health by improving neighbourhood built environments could widen health inequalities. Methods: In the UK Biobank cohort we used linked records of hospital admissions to assess the relative hazard of being admitted to hospital with a primary diagnosis of CVD according to three characteristics of the neighbourhood built environment: availability of formal PA facilities, proximity of a takeaway/fast-food store, and neighbourhood greenspace. We then examined potential effect modification of the main associations by household income and area deprivation. We used Cox proportional hazards models, adjusted for likely confounding, and calculated relative excess risks due to interaction (RERI) to assess effect modification on the additive scale. We also examined the combined modifying role of income and deprivation. Results: There were 13,809 incident CVD admissions in the sample (mean follow-up=6.8 years). Overall associations between neighbourhood exposures and CVD-related hospital admissions were weak to null. However, there was evidence of effect modification by both area deprivation and household income. Greater availability of PA facilities near home was associated with lower risk of CVD-related admission in more deprived areas, but only among people in higher-income households. Area deprivation and household income both modified the association with fast-food proximity. More greenspace was not associated with lower risk of CVD-related admission for any group. Some results differed between women and men. Findings were largely robust to alternative model specifications. Conclusions: Improving deprived neighbourhoods by increasing the number of PA facilities, while also ensuring access to these is free or affordable, may improve population health. Examining effect modification by multiple socioeconomic indicators in parallel can yield deeper insight into how different aspects of the people?s socioeconomic conditions influence their relationship with the built environment and its effects on their health. Improved understanding may help to avoid generating or perpetuating health inequalities when neighbourhood-based built environment interventions are designed.

Genetic risk of obesity as a modifier of associations between neighbourhood environment and body mass index: an observational study of 335 046 UK Biobank participants

BMJ Nutrition, Prevention & Health · 2019
K. Mason、L. Palla、N. Pearce 等

Background There is growing recognition that recent global increases in obesity are the product of a complex interplay between genetic and environmental factors. However, in gene-environment studies of obesity, ‘environment’ usually refers to individual behavioural factors that influence energy balance, whereas more upstream environmental factors are overlooked. We examined gene-environment interactions between genetic risk of obesity and two neighbourhood characteristics likely to be associated with obesity (proximity to takeaway/fast-food outlets and availability of physical activity facilities). Methods We used data from 335 046 adults aged 40–70 in the UK Biobank cohort to conduct a population-based cross-sectional study of interactions between neighbourhood characteristics and genetic risk of obesity, in relation to body mass index (BMI). Proximity to a fast-food outlet was defined as distance from home address to nearest takeaway/fast-food outlet, and availability of physical activity facilities as the number of formal physical activity facilities within 1 km of home address. Genetic risk of obesity was operationalised by weighted Genetic Risk Scores of 91 or 69 single nucleotide polymorphisms (SNP), and by six individual SNPs considered separately. Multivariable, mixed-effects models with product terms for the gene-environment interactions were estimated. Results After accounting for likely confounding, the association between proximity to takeaway/fast-food outlets and BMI was stronger among those at increased genetic risk of obesity, with evidence of an interaction with polygenic risk scores (p=0.018 and p=0.028 for 69-SNP and 91-SNP scores, respectively) and in particular with a SNP linked to MC4R (p=0.009), a gene known to regulate food intake. We found very little evidence of gene-environment interaction for the availability of physical activity facilities. Conclusions Individuals at an increased genetic risk of obesity may be more sensitive to exposure to the local fast-food environment. Ensuring that neighbourhood residential environments are designed to promote a healthy weight may be particularly important for those with greater genetic susceptibility to obesity.