洞察前沿，连接科研新知

完整作者

Florence Magrangeas、Mia Cherkaoui、Victor Bessonneau-Gaborit、Jennifer Derrien、Céline Chevalier、Catherine Guérin-Charbonnel、Benjamin Diamond、Mehmet Kemal Samur、Intergroupe Francophone du Myélome (IFM)、Cyrille Hulin、Denis Caillot、Lionel Karlin、Bertrand Arnulf、Ola Landgren、Nikhil C Munshi、Hervé Avet-Loiseau、Ludovic Martinet、Jill Corre、Aurore Perrot、Philippe Moreau、Cyrille Touzeau、Stéphane Minvielle、Eric Letouzé

作者机构

• Nantes Université, INSERM, CNRS, Université d'Angers, CRCI2NA, Nantes, France.
• Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France.
• Institut de Cancérologie de l'Ouest, Nantes, France.
• Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
• Department of Data Science, Dana Farber Cancer Institute, Boston, MA, USA.
• Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• Service d'Hématologie, Hôpital Haut Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac, France.
• Service d'Hématologie, Centre Hospitalier Universitaire de Dijon, Dijon, France.
• Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'Hematologie, Pierre-Benite, Université Claude Bernard Lyon 1, Lyon, France.
• Immuno-hématologie, Hôpital Saint Louis, APHP, Université Paris Cité, Paris, France.
• Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
• VA Boston Healthcare System, Boston, MA, USA.
• Cancer Research Center of Toulouse, INSERM, CNRS, Université Toulouse III-Paul Sabatier, Toulouse, France.
• Institut Universitaire du Cancer, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
• Université de Toulouse, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse-Oncopole, Service d'Hématologie, Toulouse, France.
• Service d'Hématologie, Centre Hospitalier Universitaire de Nantes, Nantes, France.
• Nantes Université, INSERM, CNRS, Université d'Angers, CRCI2NA, Nantes, France. stephane.minvielle@univ-nantes.fr.
• Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France. stephane.minvielle@univ-nantes.fr.
• Nantes Université, INSERM, CNRS, Université d'Angers, CRCI2NA, Nantes, France. eric.letouze@gmail.com.
• Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France. eric.letouze@gmail.com.

技术路线

423例NDMM肿瘤样本（MIDAS队列）→整合基因组、转录组和表观基因组分析→MRD关联特征在CASSIOPEIA队列独立验证；全基因组测序发现基因组不稳定表型在MMRF队列验证；驱动改变在MMRF、MANHATTAN和CASSIOPEIA三个外部队列（1,451例）独立验证；多模态随机森林模型预测MRD状态，AUC为0.77，并与临床、基因组、转录组和表观基因组模型比较

最近 5 个完整年度引用趋势

完整作者

Vishal R Patel、Samuel G Finlayson、Michael Liu-Hass、Mondira Ray、Jesse Burk-Rafel、Travis I Zack、Anupam B Jena

作者机构

• Harvard Medical School, Boston, Massachusetts.
• Brigham and Women's Hospital, Boston, Massachusetts.
• OpenEvidence, Miami, Florida.
• Seattle Children's Hospital, Seattle, Washington.
• NYU Grossman School of Medicine, New York, New York.
• Massachusetts General Hospital, Boston.
• National Bureau of Economic Research, Cambridge, Massachusetts.

技术路线

数据/样本：分析2024-01-01至2026-06-30期间OpenEvidence平台经National Provider Identifier验证的临床医生账户；对3880万条查询的分层随机样本，使用大语言模型分类临床目的和主题。分析：描述活跃用户数和查询量、查询份额相对于全国劳动力代表性的比例（use ratio），以及查询的临床目的和主题分布。验证：原文未报告独立验证。

最近 5 个完整年度引用趋势

完整作者

Tamrin Chowdhury、C Mircea S Tesileanu、Emre Kocakavuk、Kevin C Johnson、Joo Ho Lee、Zeynep Erson-Omay、Chaewon Heo、Kenneth Aldape、Samirkumar B Amin、Kevin J Anderson、David M Ashley、Floris P Barthel、Jill S Barnholtz-Sloan、Daniel J Brat、Andrew R Brodbelt、Ana Valeria Castro、Elizabeth B Claus、Jennifer M Connelly、Joseph F Costello、Indrani Datta、Carol Elliott、Gaetano Finocchiaro、Pim J French、Hui K Gan、Luciano Garofano、Padmaja L Ghospurkar、Anna Golebiewska、Pranav S Gundla、Beth Hermes、Chibo Hong、Youri Hoogstrate、Craig Horbinski、Jason T Huse、Antonio Iavarone、Cihat Karadag、Mustafa Khasraw、Mathilde C M Kouwenhoven、Peter S LaViolette、Kay Li、Allison Lowman、Katy McCortney、Hyo-Eun Moon、Nader Sanai、MacLean P Nasrallah、H K Ng、D Ryan Ormond、Bethany Kwan、Marta Padovan、Sun Ha Paek、Laila M Poisson、Sushant Puri、Erica Shen、Shwetal Mehta、Andrew E Sloan、Wies R Vallentgoed、Erwin G Van Meir、Rachael Vaubel、Taylor E Wade、Annemiek M E Walenkamp、Colin Watts、Tobias Weiss、Michael Weller、Pieter Wesseling、Kerryn Westcott、Bart A Westerman、Gordon Y Ye、W K Alfred Yung、GLASS Consortium、Frederick S Varn、Roel G W Verhaak

作者机构

• Department of Neurosurgery, Yale University, New Haven, CT, USA.
• Department of Hematology and Stem Cell Transplantation, West German Cancer Center (WTZ), National Center for Tumor Diseases (NCT) West, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
• Department of Radiation Oncology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
• Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
• National Institutes of Health, Bethesda, MD, USA.
• The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
• Preston Robert Tisch Brain Tumor Center at Duke University, Durham, NC, USA.
• Translational Genomics Research Institute, Phoenix, AZ, USA.
• National Cancer Institute, Bethesda, MD, USA.
• Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
• Walton Centre NHS Foundation Trust, Liverpool, UK.
• Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Health, Detroit, MI, USA.
• Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
• Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA.
• Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
• Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
• St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
• Department of Neurology, IRCCS Ospedale San Raffaele, Milan, Italy.
• Department of Neurology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.
• Cancer Therapies and Biology Laboratory, Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Victoria, Australia.
• Department of Public Health Sciences, Division of Biostatistics and Bioinformatics, Miller School of Medicine, University of Miami, Miami, FL, USA.
• Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.
• NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
• Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
• University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
• Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
• Department of Neurology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
• Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA.
• Department of Pathology, Prince of Wales Hospital, Hong Kong, China.
• Department of Neurosurgery, Cancer Research Institute, Hypoxia/Ischemia Disease Institute, Seoul National University, Seoul, Republic of Korea.
• Ivy Brain Tumor Center at the Barrow Neurological Institute, Phoenix, AZ, USA.
• Glioblastoma Translational Center of Excellence, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• Department of Neurosurgery, University of Colorado Anschutz School of Medicine, Aurora, CO, USA.
• Department of Emergency Medicine, University of Colorado Anschutz School of Medicine, Aurora, CO, USA.
• Advanced Institutes of Convergence Technology, Seoul National University, Suwon-si, Republic of Korea.
• Oregon Health & Science University, Portland, OR, USA.
• Neurological Institute, Premier Health and Wright State University School of Medicine, Dayton, OH, USA.
• University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
• Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.
• Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
• Department of Cancer Genome Sciences, University of Birmingham, Birmingham, UK.
• Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
• VUmc, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
• Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
• Department of Neurosurgery, VUmc, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
• University of California, San Diego, La Jolla, CA, USA.
• Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. frederick.varn@jax.org.
• Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA. frederick.varn@jax.org.
• Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA. frederick.varn@jax.org.
• Department of Neurosurgery, Yale University, New Haven, CT, USA. roel.verhaak@yale.edu.

技术路线

['数据/样本：183例IDH突变型胶质瘤患者的纵向收集肿瘤标本（来自GLASS联盟）', '分析：全基因组测序和全外显子组测序，表征纵向标本的遗传驱动因素；验证已知进展基因组标志物（超突变、CDKN2A/B纯合缺失），发现区分星形细胞瘤与少突胶质细胞瘤演化轨迹的遗传改变；分析获得性改变、全基因组变化与患者结局的趋同；关联治疗（替莫唑胺、放疗）与突变特征', '验证：验证已知基因组标志物（超突变和CDKN2A/B纯合缺失）']

最近 5 个完整年度引用趋势

完整作者

Nicolás Gómez-Banoy、Jorge A Barrero、Luiza Rachel Pinheiro de Carvalho、Caroline S Jiang、Tara Doma Lama、Nakul Karandikar、Mascha Koenen、Tiffany Lam、Kaja Plucińska、Ksenia Morozova、Stephanie Chahwan、Gustavo Barraza、Burcin Agridag Ucpinar、Jennifer E Liu、Rohit Sharma、Daniel Lafontaine、Heiko Schöder、Paul Cohen

作者机构

• Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.
• Department of Medicine, Division of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Weill Cornell Medicine, New York, NY, USA.
• Departamento de Ciencias Fisiológicas, Laboratorio de Lípidos y Diabetes, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia.
• Center for Clinical and Translational Science, The Rockefeller University, New York, NY, USA.
• Metabolic Phenotyping Center, Core Laboratories Center, Weill Cornell Medicine, New York, NY, USA.
• Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
• Laboratory of Tissue Dynamics and Organ Crosstalk, Helmholtz Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association at Heidelberg University, Mannheim, Germany.
• Department of Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.
• Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Department of Medicine, Cardiology Service, Memorial Sloan Kettering Cancer Center/Weill Cornell Medicine, New York, NY, USA.
• Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA. pcohen@rockefeller.edu.

技术路线

大数据队列（101,243例患者） → 无偏分析及机器学习半自动量化BAT活性（约8,700例）

最近 5 个完整年度引用趋势

完整作者

MacLean C Sellars、Jessica A Frank、Bohoon Shim、Allison Vanasse、Ruolin Liu、Cleo Forman、Chloe R Tu、Kyohei K Tabata、Antonia Kowelewski、Su-Chun Cheng、Catherine Song、Kan Xiong、Pia Jain、Andjela Crnjac、Haley E Sax、Vipheaviny Chea、Wesley Lu、J Thomas Janes、Micah Rickles-Young、Amit Sud、Savni Sarolkar、Martin Hayes、Oriol Olive、Haley Greenslade、Carrie Cibulskis、Nir Hacohen、Edward F Fritsch、Shuqiang Li、Kenneth J Livak、Nabihah Tayob、Elizabeth H Stover、Carolyn Krasner、Rebecca Porter、Ursula Matulonis、Gad Getz、Giacomo Oliveira、Patrick A Ott、Jeremy M Simon、Viktor A Adalsteinsson、Derin B Keskin、Panagiotis A Konstantinopoulos、Catherine J Wu

作者机构

• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• Harvard Medical School, Boston, MA, USA.
• Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
• Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
• Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
• Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
• Department of Pathology, Harvard Medical School, Boston, MA, USA.
• Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
• Department of Medical Education and Biomedical Sciences, Methodist University CFVH School of Medicine, Fayetteville, NC, USA.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Harvard Medical School, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Mellen and Eisenson Family Center for BRCA and Related Genes, Dana-Farber Cancer Institute, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Harvard Medical School, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.

技术路线

肿瘤样本/诊断活检 → 个体化新抗原筛选与合成多肽库（NeoVax）制备

最近 5 个完整年度引用趋势

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