洞察前沿，连接科研新知

完整作者

Ruiyang Zhai、Te Ma、Mu Su、Hongli Wang、Ji Li、Jie Xing、Xianhe Huang、Peishen Yu、Junyao Qiu、Ting Liu、Xingjun Xiao、Yu Li、Yue Gu、Yan Zhang

作者机构

• School of Life Science and Technology, Faculty of Life Sciences and Medicine, Harbin Institute of Technology, Harbin 150001, China.
• College of Pathology, Qiqihar Medical University, Qiqihar 161042, China.
• Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

技术路线

42,798份治疗前样本（94种疾病、510种治疗方案、377种干预、8个采样部位的4类标本，含微生物组/转录组/表观基因组数据） → 采用定制iMOD工作流进行多组学数据处理，生成20类分子特征，鉴定>184万候选特征-结局关联

最近 5 个完整年度引用趋势

暂无引用数据

完整作者

Jiahao Yuan、Xiaoxuan Gong、Chunwu Diao、Jiazhi Ren、Yingdan Wang、Aixi Bao、Ziyuan Jin、Xiuzhe Zhang、Chen Cao、Chunjian Li

作者机构

• Department of Clinical Medicine, Nanjing Medical University Tianyuan Honors School, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
• Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210000, China.
• Jiangsu Key Laboratory for Biomedical Electromagnetic Precision Theranostics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, Jiangsu 210000, China.

技术路线

UK Biobank个体数据（364,795名欧洲参与者、251项血浆NMR代谢物、129项临床测量、54项环境暴露、全基因组变异、57种发病结局） → 性别合并及性别特异性关联分析、两步筛选与自然效应模型中介分析、惩罚逻辑回归/XGBoost/LightGBM/多层感知机发病预测建模

最近 5 个完整年度引用趋势

暂无引用数据

完整作者

Donghao Li、Hao Wang、Jiyu Guo、Feng Leng、Xinran Zhi、Manyu Gong、Mengqian Zeng、Kefan Liu、Yuhong Sun、Yongsheng Li、Ying Zhang、Juan Xu

作者机构

• State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang Province 150081, China.
• State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (StateKey Laboratory-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China.
• School of Interdisciplinary Medicine and Engineering, Heilongjiang Academy of Medical Science, Harbin Medical University, Harbin 150081, China.
• Third Ward of Obstetrics and Gynecology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150086, China.

技术路线

数据/样本：来自24种癌症类型、1190份样本的肿瘤内微生物表位景观构建；分析：泛癌表位特征比较（疏水性、脂肪族指数、稳定性）、HLA-I等位基因结合倾向分析、微生物物种/表位在肿瘤中的分布与跨度分析；验证：原文报告同源微生物表位与肿瘤抗原诱导交叉反应性T细胞应答，且实验证据显示微生物表位具有增强的免疫原性和抗肿瘤效力（未提供具体实验细节）。

最近 5 个完整年度引用趋势

暂无引用数据

完整作者

Liubing Hou、Yu Wang、Xiang Zhan、Jiayuan Li、Zizhou Zhang、Weijing Cai、Linlin Su、Wei Han、Xuetao Han、Yue Han、Xiaolan Lv、Xiaoying Xue、Huandi Zhou

作者机构

• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China; Department of Central Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: houliubing2022@163.com.
• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: wy51509297@163.com.
• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: zhanxiangfriend@163.com.
• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: ljyuan19950212@163.com.
• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: zhang000428202202@163.com.
• Emergency Department, The Second Hospital of Bazhou City, Langfang, Hebei 065701, PR China. Electronic address: caidaifu@qq.com.
• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: sulinlin0405@163.com.
• Department of Oncology, Hebei General Hospital, Shijiazhuang, Hebei 050000, PR China. Electronic address: hanjue2542@sina.com.
• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: hxt9088@hebmu.edu.cn.
• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: 2241394256@qq.com.
• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: 1425744279@qq.com.
• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China; Hebei Key Laboratory of Etiology Tracing and Individualized Diagnosis and Treatment for Digestive System Carcinoma, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: xxy0636@hebmu.edu.cn.
• Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China; Hebei Key Laboratory of Etiology Tracing and Individualized Diagnosis and Treatment for Digestive System Carcinoma, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, PR China. Electronic address: huandizhou@hebmu.edu.cn.

技术路线

公共队列数据（TCGA、CGGA325、CGGA693）→RAD51表达与临床病理/预后关联分析（ROC、生存分析、Cox回归、列线图）及多组学生物信息学免疫微环境分析→临床标本蛋白表达验证

最近 5 个完整年度引用趋势

暂无引用数据

完整作者

Lihai Gong、Cheng Tan、Jinhui Zhang、Rigan Shu、Shutong Guo、Tingting Xiao、Jialin Shi、Jing Wang、Ting Ni、Ruofan Ding

作者机构

• Institutes of Biomedical Sciences, Inner Mongolia University, Hohhot 010070, China.
• College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
• State Key Laboratory of Genetic Engineering, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, Shanghai Engineering Research Center of Industrial Microorganisms, School of Life Sciences, Fudan University, Shanghai 200438, China.

技术路线

数据/样本：UK Biobank与FinnGen的1891个疾病相关表型中230,404个精细定位候选变异，整合预计算AlphaGenome 11类调控输出、bulk与单细胞xQTL、MPRA测量及GWAS-eQTL共定位结果 → 分析：按变异、表型、基因交叉检索，按需AlphaGenome预测、多组学基因组浏览器可视化及调控网络探索

最近 5 个完整年度引用趋势

完整作者

Chao Ning、Xiang Zhou

作者机构

• Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
• Department of Statistics and Data Science, Yale University, New Haven, CT, USA. xiang.zhou.xz735@yale.edu.

技术路线

数据/样本：UK Biobank的32项体格性状和67项血液生物标志物数据，辅以广泛模拟数据；分析：全基因组基因-环境交互分析（fastGxE），控制多基因效应、多基因交互效应和噪声异质性；无独立验证步骤报告

最近 5 个完整年度引用趋势

完整作者

Oveis Jamialahmadi、Shahir Mowlaei、Kyla Z Gelev、Rosellina M Mancina、Valentina Flagiello、Julia Kozlitina、Päivi Pajukanta、Luca Valenti、Stefano Romeo

作者机构

• Centre for Reproduction, Metabolism and Molecular Medicine (CeRM), Department of Medicine, Karolinska Institute, Huddinge, Sweden. oveis.jamialahmadi@ki.se.
• Centre for Reproduction, Metabolism and Molecular Medicine (CeRM), Department of Medicine, Karolinska Institute, Huddinge, Sweden.
• Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
• Department of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy.
• Operative Research Unit of Clinical Medicine and Hepatology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
• The Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
• Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.
• Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
• Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
• Precision Medicine and Biological Resource Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy.
• Centre for Reproduction, Metabolism and Molecular Medicine (CeRM), Department of Medicine, Karolinska Institute, Huddinge, Sweden. stefano.romeo@ki.se.
• Department of Endocrinology, Karolinska University Hospital, Huddinge, Sweden. stefano.romeo@ki.se.
• Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy. stefano.romeo@ki.se.
• Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden. stefano.romeo@ki.se.
• Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden. stefano.romeo@ki.se.

技术路线

MRI衍生肝脏甘油三酯含量数据（71,488名欧洲 ancestry UK Biobank参与者）→全基因组关联研究荟萃分析→识别60个独立位点（31个新位点）并估计SNP遗传力为25%→整合精细定位与基因优先级分析提名48个位点的候选效应基因→在临床诊断的代谢功能障碍相关脂肪性肝病荟萃分析（42,163例病例和1,646,254例对照）中验证31个新位点中的14个→多基因风险评分与肝硬化（OR 2.71）和肝细胞癌（OR 7.47）风险关联分析→与多基因风险评分相关的血浆蛋白通路富集分析（代谢重塑和炎症通路，肝脏富集蛋白特征增加、内脏脂肪特征减少）

最近 5 个完整年度引用趋势

完整作者

Shihao Chen、Jiaxing Wang、Qiangzhou Wang、Zhichao Zhang、Hao Bai、Guobin Chang

作者机构

• College of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, Jiangsu, 225009, China. Electronic address: mrrchen@yzu.edu.cn.
• College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, 225009, China.
• College of Animal Science and Technology, Yangzhou University, 48 East Wenhui Road, Yangzhou, Jiangsu, 225009, China.

技术路线

氨基酸/葡萄糖饥饿模型与IBDV感染相关miRNA谱整合→比较筛选营养响应型miRNA→小RNA测序及靶基因通路富集预测→gga-miR-204过表达/抑制功能实验（病毒RNA、VP2蛋白、感染性病毒产量）→荧光素酶报告基因验证MAP1LC3B 3'UTR靶向→mimic处理检测LC3-II→MAP1LC3B沉默/过表达检测VP2丰度

最近 5 个完整年度引用趋势

完整作者

Florence Magrangeas、Mia Cherkaoui、Victor Bessonneau-Gaborit、Jennifer Derrien、Céline Chevalier、Catherine Guérin-Charbonnel、Benjamin Diamond、Mehmet Kemal Samur、Intergroupe Francophone du Myélome (IFM)、Cyrille Hulin、Denis Caillot、Lionel Karlin、Bertrand Arnulf、Ola Landgren、Nikhil C Munshi、Hervé Avet-Loiseau、Ludovic Martinet、Jill Corre、Aurore Perrot、Philippe Moreau、Cyrille Touzeau、Stéphane Minvielle、Eric Letouzé

作者机构

• Nantes Université, INSERM, CNRS, Université d'Angers, CRCI2NA, Nantes, France.
• Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France.
• Institut de Cancérologie de l'Ouest, Nantes, France.
• Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
• Department of Data Science, Dana Farber Cancer Institute, Boston, MA, USA.
• Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• Service d'Hématologie, Hôpital Haut Lévêque, Centre Hospitalier Universitaire de Bordeaux, Pessac, France.
• Service d'Hématologie, Centre Hospitalier Universitaire de Dijon, Dijon, France.
• Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d'Hematologie, Pierre-Benite, Université Claude Bernard Lyon 1, Lyon, France.
• Immuno-hématologie, Hôpital Saint Louis, APHP, Université Paris Cité, Paris, France.
• Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
• VA Boston Healthcare System, Boston, MA, USA.
• Cancer Research Center of Toulouse, INSERM, CNRS, Université Toulouse III-Paul Sabatier, Toulouse, France.
• Institut Universitaire du Cancer, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
• Université de Toulouse, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse-Oncopole, Service d'Hématologie, Toulouse, France.
• Service d'Hématologie, Centre Hospitalier Universitaire de Nantes, Nantes, France.
• Nantes Université, INSERM, CNRS, Université d'Angers, CRCI2NA, Nantes, France. stephane.minvielle@univ-nantes.fr.
• Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France. stephane.minvielle@univ-nantes.fr.
• Nantes Université, INSERM, CNRS, Université d'Angers, CRCI2NA, Nantes, France. eric.letouze@gmail.com.
• Centre Hospitalier Universitaire de Nantes, Université de Nantes, Nantes, France. eric.letouze@gmail.com.

技术路线

423例NDMM肿瘤样本（MIDAS队列）→整合基因组、转录组和表观基因组分析→MRD关联特征在CASSIOPEIA队列独立验证；全基因组测序发现基因组不稳定表型在MMRF队列验证；驱动改变在MMRF、MANHATTAN和CASSIOPEIA三个外部队列（1,451例）独立验证；多模态随机森林模型预测MRD状态，AUC为0.77，并与临床、基因组、转录组和表观基因组模型比较

最近 5 个完整年度引用趋势

完整作者

Muhanad Musaad Alhujaily、Amal Adnan Ashour、Alaa Shafie、Farah Anjum、Tooba Naz Shamsi、Taj Mohammad

作者机构

• Department of Biochemistry, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; Saudi German Hospital Research Center, Middle East Healthcare Company, Jeddah, Saudi Arabia; King Salman Center for Disability Research, Riyadh, 11614, Saudi Arabia.
• Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Taif University, PO Box 11099, Taif, 21944, Saudi Arabia; King Salman Center for Disability Research, Riyadh, 11614, Saudi Arabia.
• Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O Box 11099, Taif, 21944, Saudi Arabia; King Salman Center for Disability Research, Riyadh, 11614, Saudi Arabia.
• Department of Biosciences, Faculty of Sciences, Integral University, Lucknow, 226026, India.
• Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada. Electronic address: tshamsi@ualberta.c.
• Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India. Electronic address: taj144796@st.jmi.ac.in.

技术路线

综述性文章，无原始数据/样本与分析流程；技术路线为：多组学（转录组、蛋白质组、表观基因组、代谢组、单细胞）及人工智能/机器学习方法综述→多组学整合、生物标志物优先级排序、结局预测与治疗靶点发现的分析框架讨论→指出PNI特异性临床验证有限，并提出未来转化研究中的验证设想

最近 5 个完整年度引用趋势