Artificial intelligence-enabled clinical phenotyping of human brown fat.
人工智能赋能的人类棕色脂肪临床表型分析。脂肪组织在全身能量平衡及肥胖及其并发症的发病机制中发挥核心作用。与白色脂肪组织不同，棕色脂肪组织（BAT）利用能量产热。人体可检测到的BAT与心血管代谢疾病患病率降低相关，但BAT相关的完整健康状态谱仍不明确，且缺乏高通量量化人体BAT活性的方法。本研究利用大数据和人工智能，在来自大型癌症中心的101,243例患者队列中系统定义BAT的临床影响。无偏分析显示，在所有诊断中，心血管和精神疾病在BAT阳性人群中患病率较低。采用机器学习方法对约8,700例患者的BAT活性进行半自动量化，发现较高的BAT活性（尤其是腋窝部位）与心血管代谢疾病风险降低及更健康的白色脂肪分布相关。BAT阳性者还表现出更有利的血糖参数、血脂谱、炎症标志物和超声心动图指标。用药分析显示，血管紧张素受体阻滞剂使用与BAT存在正相关。概念验证表明，氯沙坦可增加棕色脂肪细胞活性和全身能量消耗。综上，本研究利用人工智能和大数据识别了与BAT相关的新临床表型，并为靶向激活该组织的药物重定位提供了平台。
查看扩展信息
完整作者
Nicolás Gómez-Banoy、Jorge A Barrero、Luiza Rachel Pinheiro de Carvalho、Caroline S Jiang、Tara Doma Lama、Nakul Karandikar、Mascha Koenen、Tiffany Lam、Kaja Plucińska、Ksenia Morozova、Stephanie Chahwan、Gustavo Barraza、Burcin Agridag Ucpinar、Jennifer E Liu、Rohit Sharma、Daniel Lafontaine、Heiko Schöder、Paul Cohen
作者机构
- Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.
- Department of Medicine, Division of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Weill Cornell Medicine, New York, NY, USA.
- Departamento de Ciencias Fisiológicas, Laboratorio de Lípidos y Diabetes, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia.
- Center for Clinical and Translational Science, The Rockefeller University, New York, NY, USA.
- Metabolic Phenotyping Center, Core Laboratories Center, Weill Cornell Medicine, New York, NY, USA.
- Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
- Laboratory of Tissue Dynamics and Organ Crosstalk, Helmholtz Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association at Heidelberg University, Mannheim, Germany.
- Department of Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.
- Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- Department of Medicine, Cardiology Service, Memorial Sloan Kettering Cancer Center/Weill Cornell Medicine, New York, NY, USA.
- Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA. pcohen@rockefeller.edu.
技术路线
大数据队列（101,243例患者） → 无偏分析及机器学习半自动量化BAT活性（约8,700例）
最近 5 个完整年度引用趋势
不含 2026 年，仅展示最近 5 个完整年度。
为什么值得关注
暂未整理