本研究回顾性纳入2000至2022年孕前糖尿病（PDM）单胎妊娠孕妇，分析血糖、糖化血红蛋白（HbA1c）、血脂、动脉血pH、电解质及阴离子间隙等代谢指标，采用ROC曲线和logistic回归评估其预测糖尿病酮症酸中毒（DKA）及围产期死亡的价值。219例孕妇中21例（9.6%）发生DKA，其血糖（395.33 vs. 126.91 mg/dL）、HbA1c（8.45% vs. 6.73%）、LDL较高，HDL较低（均P<0.05）。围产期死亡6例（28.6%），与较低动脉血pH、较低碳酸氢盐、较宽阴离子间隙、较高HbA1c及高钾血症相关。联合代谢指标的ROC曲线下面积分别为0.99（DKA）和0.98（围产期死亡）。HbA1c升高、HDL降低及血糖升高为DKA的独立预测因素，碳酸氢盐降低与围产期死亡风险增加独立相关；碳酸氢盐<6.50 mEq/L与围产期死亡显著相关（P<0.001）。关键代谢指标有助于PDM孕妇DKA及围产期死亡的风险分层。
Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan.
Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan.
Department of Obstetrics and Gynecology, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical University, New Taipei City, Taiwan. Electronic address: f122481@mmh.org.tw.
临床队列临床研究Taiwanese journal of obstetrics & gynecology
Frequent blastocyst contractions with area reduction >30% are associated with reduced embryo quality but not IVF outcomes: A retrospective cohort study of fresh and frozen single embryo transfer.
Chia-Chen Lee、Kuan-Sheng Lee、Christine Shan-Chi Chiu、Robert Kuo-Kuang Lee、Ming-Huei Lin
作者机构
Division of Reproduction and Infertility, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taiwan.
Division of Reproduction and Infertility, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taiwan. Electronic address: huei97@mmh.org.tw.
Nutrition Innovation Centre for Food and Health, School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland. Electronic address: h.mcnulty@ulster.ac.uk.
Machine Learning-Guided Virtual Screening Identifies a Novel MELK-Targeted Antiproliferative Lead Compound with G2/M Arrest Activity in Triple-Negative Breast Cancer and Lung Adenocarcinoma Cells.
Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
School of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang 117004, China.
School of Pharmacy, Henan University, Kaifeng 475004, China.
Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China.
Srilaxmi Bearelly、Cassandra Areff、Matthew K Hoffman、Daniel Sunko、Andrew F Laine、Bin Choi、Hanna Rodriguez Coleman、Bianca Cordazzo Vargas、Chloe Y Li、Jennifer J Dawkins、Emily Amir、Sahar Paz、Lisa A Hark、Whitney A Booker、April A Jauhal、Justin S Brandt、Ronald J Wapner、Liat Shenhav
作者机构
Department of Ophthalmology, Columbia University Irving Medical Center, New York, NY, USA.
Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.
Institute for Systems Genetics, NYU Grossman School of Medicine, New York University, New York, NY, USA.
Division of Obstetrics and Gynecology, ChristianaCare, Newark, DE, USA.
Department of Biomedical Engineering, Columbia University, New York, NY, USA.
Department of Radiology, Columbia University Irving Medical Center, New York, NY, USA.
Center for Health Analytics, Data Science Institute, Columbia University, New York, NY, USA.
Department of Obstetrics and Gynecology, NYU Grossman School of Medicine, New York University, New York, NY, USA.
Institute for Systems Genetics, NYU Grossman School of Medicine, New York University, New York, NY, USA. liat.shenhav@nyulangone.org.
Department of Microbiology, NYU Grossman School of Medicine, New York University, New York, NY, USA. liat.shenhav@nyulangone.org.
Department of Obstetrics and Gynecology, NYU Grossman School of Medicine, New York University, New York, NY, USA. liat.shenhav@nyulangone.org.
Department of Computer Science, Courant Institute of Mathematical Sciences, New York University, New York, NY, USA. liat.shenhav@nyulangone.org.
Sian Liu、Wenxin Zheng、Jin Kang、Tianyi Xu、Siming Chen、Gen Li、Junlong Li、Hang Wong、Meihao Wang、Xiaokai Bai、Changxi Hu、Cheng Tang、Shengwei Jin、Zixing Zou、Ieng Chong、Yuxing Lu、Io Nam Wong、Hui Xu、Charlotte L Zhang、Jingman Shi、Erhu Feng、Jinyu Gu、Zhuo Sun、Haibo Chen、Li Yang、Yuan Zhang、Xian Zhu、Huanhuan Huang、Xiuyuan Xu、Xue Li、Zhenhui Zhao、Hongbo Qi、Xinyu Lu、Ngaman Cheng、Sicheng Pan、Ning Sun、Yun Yin、Michelle Williams、Eric Oermann、John E J Rasko、Jin Li、Kai Wang、Kang Zhang、Hao Wu、Yubin Xia、Fanxin Zeng、International Consortium of Digital Twins in Healthcare and Medicine
作者机构
Center for Big Data and Intelligent Medicine, The First Affiliated Hospital of Chongqing Medical University; Key Laboratory of Digital Health and Intelligent Medicine, Chongqing Municipal Health Commission and Chongqing Translational Medicine Center, Chongqing, China.
State Key Lab of Eye Health and Clinical Data Science Institute, Institute for Advanced Study on Eye Health and Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Department of Computer Science, Shanghai Jiao Tong University, Shanghai, China.
Artificial Intelligence Cross Disciplinary Research Institute and Faculty of Medicine, Macau University of Science and Technology, Macau, China.
Department of Radiology, Department of Anesthesia and Critical Care, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, China.
Guangzhou National Laboratory, Guangzhou, China.
Department of Big Data and Biomedical AI, College of Future Technology, Peking University, Beijing, China.
College of Computer Science, Sichuan University, Chengdu, China.
Department of Clinical Research Center, Dazhou Central Hospital and Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Dazhou, China.
Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Baichuan Inc., Beijing, China.
Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Departments of Neurosurgery, Radiology and Data Science, Neuroscience Institute, NYU Langone Medical Center, New York University, New York, NY, USA.
Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.
College of Life Science, Fudan University, Shanghai, China. li_jin_lifescience@fudan.edu.cn.
Artificial Intelligence Cross Disciplinary Research Institute and Faculty of Medicine, Macau University of Science and Technology, Macau, China. kaiwang314@gmail.com.
State Key Lab of Eye Health and Clinical Data Science Institute, Institute for Advanced Study on Eye Health and Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China. kang.zhang@gmail.com.
Artificial Intelligence Cross Disciplinary Research Institute and Faculty of Medicine, Macau University of Science and Technology, Macau, China. kang.zhang@gmail.com.
Guangzhou National Laboratory, Guangzhou, China. kang.zhang@gmail.com.
Center for Big Data and Intelligent Medicine, The First Affiliated Hospital of Chongqing Medical University; Key Laboratory of Digital Health and Intelligent Medicine, Chongqing Municipal Health Commission and Chongqing Translational Medicine Center, Chongqing, China. wuhao@cqmu.edu.cn.
Department of Computer Science, Shanghai Jiao Tong University, Shanghai, China. xiayubin@sjtu.edu.cn.
Department of Clinical Research Center, Dazhou Central Hospital and Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Dazhou, China. zengfx@pku.edu.cn.
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