洞察前沿，连接科研新知

完整作者

暂未整理

作者机构

暂未整理

技术路线

暂未整理

最近 5 个完整年度引用趋势

暂无引用数据

完整作者

暂未整理

作者机构

暂未整理

技术路线

暂未整理

最近 5 个完整年度引用趋势

暂无引用数据

完整作者

Juan Han、Linming Zhang、Chunyan Lei

作者机构

• Department of Neurology, Hospital of Kunming Medical University; hanjuan@ydyy.cn.
• Department of Neurology, Hospital of Kunming Medical University.

技术路线

暂未整理

最近 5 个完整年度引用趋势

暂无引用数据

完整作者

Martin Reck、Ernest Nadal、Carl M Gay、Nicolas Girard、Andrea Riccardo Filippi、Linda W Martin、Cordula Petersen、David A Cairns、Margarita Majem、Andrea Ardizzoni、Rosa Alvarez Alvarez、Andrew Robinson、Benoit Roch、Arnaud Boyer、Ilaria Attili、Maximilian Diehn、David Kurtz、Ugochinyere A Emeribe、Ignacio Diaz Perez、Matteo Giaj Levra、Davina Gale、Zhou Zhu、Nefeli Georgoulia、Jonathan Spicer

作者机构

• Lung Clinic Großhansdorf, Airway Research Center North, German Center for Lung Research, Großhansdorf, Germany. m.reck@lungenclinic.de.
• Department of Medical Oncology, Institut Català d'Oncologia (ICO), IDIBELL, Bellvitge Healthcare Campus, L'Hospitalet de Llobregat, Barcelona, Spain.
• Thoracic/Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• Institut du Thorax Curie-Montsouris, Institut Curie/UVSQ, Paris, France.
• Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
• Department of Oncology, University of Milan, Milan, Italy.
• Division of Thoracic Surgery, Department of Surgery, University of Virginia, Charlottesville, VA, USA.
• Department of Radiotherapy and Radiation Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
• Leeds Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.
• Department of Medical Oncology, Institut de Recerca Sant Pau (IR Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
• Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
• Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
• Medical Oncology Department, Hospital Universitario Gregorio Marañón, Madrid, Spain.
• Cancer Centre of Southeastern Ontario at Kingston General Hospital, Kingston, ON, Canada.
• Centre Hospitalier Universitaire de Montpellier, Montpellier, France.
• Hôpital Saint Joseph, Marseille, France.
• Division of Thoracic Oncology, European Institute of Oncology, IRCCS, Milan, Italy.
• Department of Radiation Oncology, Stanford University, Stanford, CA, USA.
• Division of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA.
• AstraZeneca, Wilmington, DE, USA.
• AstraZeneca, Gaithersburg, MD, USA.
• AstraZeneca, Cambridge, UK.
• Department of Thoracic Surgery, McGill University, Montreal, QC, Canada.

技术路线

数据/样本：142例可切除或临界可切除NSCLC患者接受新辅助治疗（64.8%可切除，35.2%临界可切除） → 分析：描述性主要终点总体切除率（74.6%，95%CI 66.7-81.6），R0切除率96.2%（90.6-99.0），并报告无事件生存、无进展生存、病理完全缓解率、循环肿瘤DNA清除及安全性

最近 5 个完整年度引用趋势

完整作者

Heinz Wiendl、Robert Bermel、Laura Airas、Tanuja Chitnis、Jin Nakahara、Mitzi Williams、Monika Adamczyk-Sowa、Karolina Piasecka-Stryczynska、Ronald Zielman、Sinead Dunphy、Nicolas Panchaud、Min Cai、Jing Xi、Brett Loop、Wendy Su、Roman Willi、Xavier Montalban、REMODEL Investigators

作者机构

• Department of Neurology and Neurophysiology, University of Freiburg, Freiburg, Germany; Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia. Electronic address: heinz.wiendl@uniklinik-freiburg.de.
• Department of Neurology, Mellen Center for Multiple Sclerosis, Cleveland Clinic, Cleveland, OH, USA.
• Turku PET Centre, Clinical Neurosciences and InFLAMES Research Flagship, University of Turku, Turku, Finland; Neurocenter, Turku University Hospital, Turku, Finland.
• Brigham Multiple Sclerosis Center and Division of Neuroimmunology, Mass General Brigham, Boston, MA, USA.
• Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
• Joi Life Wellness Neurology Clinic, Smyrna, GA, USA.
• Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland.
• MedPolonia, Outpatient MS Clinic, Poznań, Poland; Department of Medical Education and Communication, Poznan University of Medical Sciences, Poznań, Poland.
• Novartis Pharma, Basel, Switzerland.
• Novartis Ireland, Dublin, Ireland.
• Novartis Institutes for Biomedical Research, Shanghai, China.
• Novartis Pharmaceuticals Corporation, Cambridge, MA, USA.
• Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA.
• Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d'Hebron, Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), Barcelona, Spain.

技术路线

数据/样本：REMODEL-1和REMODEL-2两项相同的随机、双盲、双模拟、活性对照、平行组、事件驱动3期试验，46国407中心，共随机2007例复发型多发性硬化成人患者（REMODEL-1 1000例，REMODEL-2 1007例）。分析：主要终点为年化复发率（ARR），在意向治疗（所有随机分配）人群中评估，比较remibrutinib 100 mg每日两次与特立氟胺14 mg每日一次，并报告安全性。验证：原文未报告独立验证或额外确认性分析。

最近 5 个完整年度引用趋势

完整作者

Chao Ning、Xiang Zhou

作者机构

• Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
• Department of Statistics and Data Science, Yale University, New Haven, CT, USA. xiang.zhou.xz735@yale.edu.

技术路线

数据/样本：UK Biobank的32项体格性状和67项血液生物标志物数据，辅以广泛模拟数据；分析：全基因组基因-环境交互分析（fastGxE），控制多基因效应、多基因交互效应和噪声异质性；无独立验证步骤报告

最近 5 个完整年度引用趋势

完整作者

Oveis Jamialahmadi、Shahir Mowlaei、Kyla Z Gelev、Rosellina M Mancina、Valentina Flagiello、Julia Kozlitina、Päivi Pajukanta、Luca Valenti、Stefano Romeo

作者机构

• Centre for Reproduction, Metabolism and Molecular Medicine (CeRM), Department of Medicine, Karolinska Institute, Huddinge, Sweden. oveis.jamialahmadi@ki.se.
• Centre for Reproduction, Metabolism and Molecular Medicine (CeRM), Department of Medicine, Karolinska Institute, Huddinge, Sweden.
• Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
• Department of Life Science, Health, and Health Professions, Link Campus University, Rome, Italy.
• Operative Research Unit of Clinical Medicine and Hepatology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
• The Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.
• Bioinformatics Interdepartmental Program, UCLA, Los Angeles, CA, USA.
• Institute for Precision Health, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
• Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
• Precision Medicine and Biological Resource Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy.
• Centre for Reproduction, Metabolism and Molecular Medicine (CeRM), Department of Medicine, Karolinska Institute, Huddinge, Sweden. stefano.romeo@ki.se.
• Department of Endocrinology, Karolinska University Hospital, Huddinge, Sweden. stefano.romeo@ki.se.
• Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy. stefano.romeo@ki.se.
• Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden. stefano.romeo@ki.se.
• Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden. stefano.romeo@ki.se.

技术路线

MRI衍生肝脏甘油三酯含量数据（71,488名欧洲 ancestry UK Biobank参与者）→全基因组关联研究荟萃分析→识别60个独立位点（31个新位点）并估计SNP遗传力为25%→整合精细定位与基因优先级分析提名48个位点的候选效应基因→在临床诊断的代谢功能障碍相关脂肪性肝病荟萃分析（42,163例病例和1,646,254例对照）中验证31个新位点中的14个→多基因风险评分与肝硬化（OR 2.71）和肝细胞癌（OR 7.47）风险关联分析→与多基因风险评分相关的血浆蛋白通路富集分析（代谢重塑和炎症通路，肝脏富集蛋白特征增加、内脏脂肪特征减少）

最近 5 个完整年度引用趋势

完整作者

Tamrin Chowdhury、C Mircea S Tesileanu、Emre Kocakavuk、Kevin C Johnson、Joo Ho Lee、Zeynep Erson-Omay、Chaewon Heo、Kenneth Aldape、Samirkumar B Amin、Kevin J Anderson、David M Ashley、Floris P Barthel、Jill S Barnholtz-Sloan、Daniel J Brat、Andrew R Brodbelt、Ana Valeria Castro、Elizabeth B Claus、Jennifer M Connelly、Joseph F Costello、Indrani Datta、Carol Elliott、Gaetano Finocchiaro、Pim J French、Hui K Gan、Luciano Garofano、Padmaja L Ghospurkar、Anna Golebiewska、Pranav S Gundla、Beth Hermes、Chibo Hong、Youri Hoogstrate、Craig Horbinski、Jason T Huse、Antonio Iavarone、Cihat Karadag、Mustafa Khasraw、Mathilde C M Kouwenhoven、Peter S LaViolette、Kay Li、Allison Lowman、Katy McCortney、Hyo-Eun Moon、Nader Sanai、MacLean P Nasrallah、H K Ng、D Ryan Ormond、Bethany Kwan、Marta Padovan、Sun Ha Paek、Laila M Poisson、Sushant Puri、Erica Shen、Shwetal Mehta、Andrew E Sloan、Wies R Vallentgoed、Erwin G Van Meir、Rachael Vaubel、Taylor E Wade、Annemiek M E Walenkamp、Colin Watts、Tobias Weiss、Michael Weller、Pieter Wesseling、Kerryn Westcott、Bart A Westerman、Gordon Y Ye、W K Alfred Yung、GLASS Consortium、Frederick S Varn、Roel G W Verhaak

作者机构

• Department of Neurosurgery, Yale University, New Haven, CT, USA.
• Department of Hematology and Stem Cell Transplantation, West German Cancer Center (WTZ), National Center for Tumor Diseases (NCT) West, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
• Department of Radiation Oncology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
• Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea.
• National Institutes of Health, Bethesda, MD, USA.
• The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.
• Preston Robert Tisch Brain Tumor Center at Duke University, Durham, NC, USA.
• Translational Genomics Research Institute, Phoenix, AZ, USA.
• National Cancer Institute, Bethesda, MD, USA.
• Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
• Walton Centre NHS Foundation Trust, Liverpool, UK.
• Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Health, Detroit, MI, USA.
• Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA.
• Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA.
• Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
• Department of Neurosurgery, University of California, San Francisco, San Francisco, CA, USA.
• St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
• Department of Neurology, IRCCS Ospedale San Raffaele, Milan, Italy.
• Department of Neurology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands.
• Cancer Therapies and Biology Laboratory, Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Victoria, Australia.
• Department of Public Health Sciences, Division of Biostatistics and Bioinformatics, Miller School of Medicine, University of Miami, Miami, FL, USA.
• Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.
• NORLUX Neuro-Oncology Laboratory, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
• Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
• University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• Department of Neurological Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.
• Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
• Department of Neurology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
• Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA.
• Department of Pathology, Prince of Wales Hospital, Hong Kong, China.
• Department of Neurosurgery, Cancer Research Institute, Hypoxia/Ischemia Disease Institute, Seoul National University, Seoul, Republic of Korea.
• Ivy Brain Tumor Center at the Barrow Neurological Institute, Phoenix, AZ, USA.
• Glioblastoma Translational Center of Excellence, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• Department of Neurosurgery, University of Colorado Anschutz School of Medicine, Aurora, CO, USA.
• Department of Emergency Medicine, University of Colorado Anschutz School of Medicine, Aurora, CO, USA.
• Advanced Institutes of Convergence Technology, Seoul National University, Suwon-si, Republic of Korea.
• Oregon Health & Science University, Portland, OR, USA.
• Neurological Institute, Premier Health and Wright State University School of Medicine, Dayton, OH, USA.
• University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
• Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.
• Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
• Department of Cancer Genome Sciences, University of Birmingham, Birmingham, UK.
• Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
• VUmc, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
• Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
• Department of Neurosurgery, VUmc, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
• University of California, San Diego, La Jolla, CA, USA.
• Department of Neuro-Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA. frederick.varn@jax.org.
• Department of Genetics and Genome Sciences, University of Connecticut Health Center, Farmington, CT, USA. frederick.varn@jax.org.
• Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA. frederick.varn@jax.org.
• Department of Neurosurgery, Yale University, New Haven, CT, USA. roel.verhaak@yale.edu.

技术路线

['数据/样本：183例IDH突变型胶质瘤患者的纵向收集肿瘤标本（来自GLASS联盟）', '分析：全基因组测序和全外显子组测序，表征纵向标本的遗传驱动因素；验证已知进展基因组标志物（超突变、CDKN2A/B纯合缺失），发现区分星形细胞瘤与少突胶质细胞瘤演化轨迹的遗传改变；分析获得性改变、全基因组变化与患者结局的趋同；关联治疗（替莫唑胺、放疗）与突变特征', '验证：验证已知基因组标志物（超突变和CDKN2A/B纯合缺失）']

最近 5 个完整年度引用趋势

完整作者

MacLean C Sellars、Jessica A Frank、Bohoon Shim、Allison Vanasse、Ruolin Liu、Cleo Forman、Chloe R Tu、Kyohei K Tabata、Antonia Kowelewski、Su-Chun Cheng、Catherine Song、Kan Xiong、Pia Jain、Andjela Crnjac、Haley E Sax、Vipheaviny Chea、Wesley Lu、J Thomas Janes、Micah Rickles-Young、Amit Sud、Savni Sarolkar、Martin Hayes、Oriol Olive、Haley Greenslade、Carrie Cibulskis、Nir Hacohen、Edward F Fritsch、Shuqiang Li、Kenneth J Livak、Nabihah Tayob、Elizabeth H Stover、Carolyn Krasner、Rebecca Porter、Ursula Matulonis、Gad Getz、Giacomo Oliveira、Patrick A Ott、Jeremy M Simon、Viktor A Adalsteinsson、Derin B Keskin、Panagiotis A Konstantinopoulos、Catherine J Wu

作者机构

• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• Harvard Medical School, Boston, MA, USA.
• Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
• Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
• Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
• Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
• Department of Pathology, Harvard Medical School, Boston, MA, USA.
• Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
• Department of Medical Education and Biomedical Sciences, Methodist University CFVH School of Medicine, Fayetteville, NC, USA.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Harvard Medical School, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Mellen and Eisenson Family Center for BRCA and Related Genes, Dana-Farber Cancer Institute, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Harvard Medical School, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.

技术路线

肿瘤样本/诊断活检 → 个体化新抗原筛选与合成多肽库（NeoVax）制备

最近 5 个完整年度引用趋势

完整作者

暂未整理

作者机构

暂未整理

技术路线

暂未整理

最近 5 个完整年度引用趋势

暂无引用数据