洞察前沿，连接科研新知

完整作者

Liujia Qian、Zizhuo Zhou、Peijie Zhou、Zhen Dong、Xudong Zhang、Zhenwu Dai、Zhangyang Gao、Siqi Sun、Kevin R Roy、Shuaiyao Wang、Nicola Zamboni、Charles Boone、Michael Costanzo、Jianzhe Li、Gianni Liti、Jia-Xing Yue、Markus Ralser、Evan Williams、Mattia Zampieri、Heng Jiang、Tailin Wu、Yalin Wang、Feiran Li、Joseph Schacherer、Rui Sun、Zhaoxing Li、Yaming Deng、Yi Chen、Zhiping Xie、Huiqiang Lou、Xiaowen Wang、Linhai Xie、Han Wen、Liangyi Chen、Kai Lei、George Rosenberger、Xue Cai、Yingrui Wang、Qi Xiao、Huaizong Shen、Gaowen Liu、Lei Ma、Brenda Andrews、Hui Lu、Kiryl Piatkevich、Yi Zhu、Lei Bai、Yizhi Cai、Yuping Chen、Weinan E、Ge Gao、Fuchu He、Luonan Chen、Stan Z Li、Hongwu Ma、Liang Qiao、Lars M Steinmetz、Leihan Tang、Tang Tang、Xiaofan Zhang、Jing Yang、Yifan Yang、Kaicheng Yu、Jianyang Zeng、Yefeng Zheng、Bowen Zhou、Tiannan Guo

作者机构

• Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
• Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
• Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China.
• Center for Machine Learning Research, Peking University, Beijing, China.
• AI for Science Institute, Beijing, China.
• National Engineering Laboratory for Big Data Analysis and Applications, Beijing, China.
• Center for Data Science, Peking University, Beijing, China.
• Shanghai Artificial Intelligence Laboratory, Shanghai, China.
• Research Institute of Intelligent Complex Systems, Fudan University, Shanghai, China.
• Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
• Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
• Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
• The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
• Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
• Institute of Research on Cancer and Ageing of Nice (IRCAN), Faculté de Médecine, Nice, France.
• State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
• Department of Biochemistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
• Exploratory Diagnostic Sciences, Berlin Institute of Health at Charité, Berlin, Germany.
• Center for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
• Max Planck Institute for Molecular Genetics, Berlin, Germany.
• Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
• Department of Biomedicine, University of Basel, Basel, Switzerland.
• Department of Artificial Intelligence, School of Engineering, Westlake University, Hangzhou, China.
• Biomedical Research Core Facilities, Westlake University, Hangzhou, China.
• Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
• Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104-UMR-S 1258, Illkirch, France.
• State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
• South China Hospital, Health Science Center, Guangdong Key Laboratory of Genome Instability and Disease Prevention, Shenzhen University School of Medicine, Shenzhen, China.
• State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing, China.
• International Academy of Phronesis Medicine (Guangdong), Guangzhou, China.
• DP Technology Co. Ltd., Beijing, China.
• Beijing Advanced Center of RNA Biology (BEACON), Peking University, Beijing, China.
• State Key Laboratory of Medical Proteomics, Beijing, China.
• State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Center for Life Sciences, College of Future Technology, Peking University, Beijing, China.
• Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
• Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.
• Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China.
• Bruker Switzerland AG, Faellanden, Switzerland.
• Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China.
• Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
• National Biomedical Imaging Center, College of Future Technology, Peking University, Beijing, China.
• State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
• SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, MoE Key Lab of Artificial Intelligence, AI Institute Shanghai Jiao Tong University, Shanghai, China.
• Shanghai Engineering Research Center for Big Data in Pediatric Precision Medicine, NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
• School of Life Sciences, Westlake University, Hangzhou, China.
• Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China.
• Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.
• Generative and Synthetic Genomics, Wellcome Sanger Institute, Cambridge, UK.
• Shenzhen Institute of Synthetic Biology, Chinese Academy of Sciences, Shenzhen, China.
• Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
• School of Mathematical Sciences, Peking University, Beijing, China.
• State Key Laboratory of Gene Function and Modulation Research, Biomedical Pioneering Innovative Center (BIOPIC) and Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Center for Bioinformatics (CBI), Peking University, Beijing, China.
• School of Mathematical Sciences and School of AI, Shanghai Jiao Tong University, Shanghai, China.
• AI Laboratory, Research Center for Industries of the Future, Westlake University, Hangzhou, China.
• Biodesign Center, State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
• National Center of Technology Innovation for Synthetic Biology, Tianjin, China.
• Department of Chemistry, Fudan University, Shanghai, China.
• Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
• DZHK (German Centre for Cardiovascular Research), Heidelberg, Germany.
• Stanford Genome Technology Center, Palo Alto, CA, USA.
• Center for Interdisciplinary Studies, Westlake University, Hangzhou, China.
• Wuhan Metware Biotechnology Co. Ltd., Wuhan, China.
• Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, China.
• State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Lifeomics, Beijing, China.
• School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
• Autolab, Westlake University, Hangzhou, China.
• School of Engineering, Research Center for Industries of the Future, Westlake University, Hangzhou, China.
• Medical Artificial Intelligence Laboratory, Westlake University, Hangzhou, China.
• Department of Electronic Engineering, Tsinghua University, Beijing, China.
• Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China. guotiannan@westlake.edu.cn.
• Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. guotiannan@westlake.edu.cn.
• Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China. guotiannan@westlake.edu.cn.

技术路线

多模态生物数据与机理知识、亚细胞结构、动态状态三类数据支柱 → 细胞复杂性分解为八个功能模块（遗传、代谢、结构系统），各模块为领域AI工具并由大语言模型调度层协调

最近 5 个完整年度引用趋势

完整作者

Daniel J Baker、Leon M Frommer、Ugur Uslu、Kisha K Patel、Daniel Zhu、Nils W Engel、James M George、Wencao Zhao、Samuel I Kim、Lisa Sun、Christopher Roselle、Philipp C Rommel、Regina M Young、Jonathan A Epstein、Sikander Hayat、Zoltan Arany、Carl H June

作者机构

• Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bakerdj@upenn.edu.
• Department of Medicine 2, RWTH Aachen University, Medical Faculty, Aachen, Germany.
• Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, 97080 Würzburg, Germany.
• Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
• Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.
• Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
• Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
• Department of Medicine 2, RWTH Aachen University, Medical Faculty, Aachen, Germany; Cardiovascular Research Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Windreich Department of Artificial Intelligence and Human Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: shayat@ukaachen.de.
• Cardiovascular Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: zarany@upenn.edu.
• Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Parker Institute for Cancer Immunotherapy at University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: cjune@upenn.edu.

技术路线

单细胞RNA测序数据（人类皮肤癌与健康组织）整合→AI驱动候选靶点筛选，结合公共数据集优化肿瘤组成、组织特异性与临床可行性→大语言模型优先排序与提名→GPNMB跨血液与实体瘤表达验证→构建人源GPNMB CAR T细胞→单核细胞白血病、黑色素瘤和结直肠腺癌小鼠模型抗肿瘤活性验证

最近 5 个完整年度引用趋势

完整作者

Juraj Gottweis、Wei-Hung Weng、Alexander Daryin、Tao Tu、Petar Sirkovic、Artiom Myaskovsky、Grzegorz Glowaty、Felix Weissenberger、Alessio Orlandi、Dan Popovici、Anil Palepu、Keran Rong、Ryutaro Tanno、Khaled Saab、Fan Zhang、Jacob Blum、Andrew Carroll、Kavita Kulkarni、Nenad Tomašev、Dina Zverinski、Ivor Rendulic、Elahe Vedadi、Florian Hasler、Luka Rimanic、Marina Boia、Ivan Budiselic、Ben Feinstein、Mathias Bellaiche、Tom Sheffer、Jan Freyberg、Jeremy Ratcliff、Ottavia Bertolli、Katherine Chou、Avinatan Hassidim、Burak Gokturk、Amin Vahdat、Yuan Guan、Vikram Dhillon、Eeshit Dhaval Vaishnav、Byron Lee、Tiago R D Costa、José R Penadés、Gary Peltz、Yossi Matias、James Manyika、Demis Hassabis、Yunhan Xu、Pushmeet Kohli、Annalisa Pawlosky、Alan Karthikesalingam、Vivek Natarajan

作者机构

• Google Cloud AI Research, Zurich, Switzerland. juro@google.com.
• Google DeepMind, Mountain View, CA, USA. ckbjimmy@google.com.
• Google Cloud AI Research, Zurich, Switzerland.
• Google DeepMind, Mountain View, CA, USA.
• Google Research, Mountain View, CA, USA.
• Stanford University School of Medicine, Palo Alto, CA, USA.
• Houston Methodist Hospital, Houston, TX, USA.
• Sequome, San Francisco, CA, USA.
• Fleming Initiative and Imperial College London, London, UK.
• Google DeepMind, Mountain View, CA, USA. pushmeet@google.com.
• Google Research, Mountain View, CA, USA. apawlosky@google.com.
• Google DeepMind, Mountain View, CA, USA. alankarthi@google.com.
• Google DeepMind, Mountain View, CA, USA. natviv@google.com.

技术路线

研究目标与科学证据输入→多智能体（基于Gemini）异步任务执行与锦标赛演化生成/批判/优化假设→自动化评估（测试时算力扩展）→三个生物医学应用（药物重定位、新靶点发现、抗菌素耐药机制解释）→急性髓系白血病候选药物与协同组合的体外实验验证

最近 5 个完整年度引用趋势

完整作者

Simran Gambhir、Shweta Pandey、Harsh Bajetha、Jasleen Kaur、Ankita Das、Gnanasekar Pranavathiyani、Rupali Aggarwal、Upasana Maity、Suhani Dange、Vipin Singh、Mayur Zarkar、Raghav Sankhdher、Bhupender Singh、Shivani Seth、Anshu Bhardwaj

作者机构

• Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, India.
• Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
• UM-DAE Centre for Excellence in Basic Sciences, School of Biological Sciences, University of Mumbai Kalina Campus, Mumbai 400098, India.
• Life Sciences Department, J.C. Bose University of Science and Technology, YMCA, Sector 6, Mathura road, Faridabad Haryana 121006, India.
• Independent Researcher, IMTECH Housing, Sector 39A, Chandigarh 160036, India.

技术路线

数据/样本：聚焦WHO细菌优先病原体的参考基因组、泛基因组、AST谱、转录组数据集及多类注释资源（ARG、毒力因子、结构、宿主-病原互作、BGC、药物靶点等） → 分析：使用自建流程进行数据分析和注释，并按CLSI AST标准、EUCAST基因组序列指南及FAIR原则进行质量检查与人工整理

最近 5 个完整年度引用趋势

完整作者

Khoa Ngo、Pei-Chi Yang、Vladimir Yarov-Yarovoy、Colleen E Clancy、Igor Vorobyov

作者机构

• Center for Precision Medicine and Data Science, University of California, Davis, Davis, United States.
• Department of Physiology and Membrane Biology, University of California, Davis, Davis, United States.
• Department of Anesthesiology and Pain Medicine, University of California, Davis, Davis, United States.
• Department of Pharmacology, University of California, Davis, Davis, United States.

技术路线

结构模板引导AlphaFold预测hERG通道不同构象状态→与实验数据（状态依赖性结构特征、分子对接药物相互作用、分子动力学离子传导特性）比较验证→利用预测状态进行计算筛选并与实验药物亲和力比较→映射闭合/开放/失活态的残基相互作用网络，关键残基由既往突变研究验证

最近 5 个完整年度引用趋势

完整作者

Josephine Yates、Eliezer M Van Allen

作者机构

• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Institute for Machine Learning, Department of Computer Science, ETH Zürich, Zurich, Switzerland; ETH AI Center, ETH Zurich, Zurich, Switzerland; Swiss Institute for Bioinformatics (SIB), Lausanne, Switzerland.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Division of Medical Sciences, Harvard University, Boston, MA, USA; Parker Institute for Cancer Immunotherapy, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: eliezerm_vanallen@dfci.harvard.edu.

技术路线

多组学数据集（单细胞与空间 profiling 数据） → AI 计算分析（细胞异质性、肿瘤微环境互作、靶点发现、生物标志物识别、患者分层、治疗反应预测、AI 辅助诊断）

最近 5 个完整年度引用趋势

完整作者

Feng Ren、Alex Aliper、Jian Chen、Heng Zhao、Sujata Rao、Christoph Kuppe、Ivan V Ozerov、Man Zhang、Klaus Witte、Chris Kruse、Vladimir Aladinskiy、Yan Ivanenkov、Daniil Polykovskiy、Yanyun Fu、Eugene Babin、Junwen Qiao、Xing Liang、Zhenzhen Mou、Hui Wang、Frank W Pun、Pedro Torres-Ayuso、Alexander Veviorskiy、Dandan Song、Sang Liu、Bei Zhang、Vladimir Naumov、Xiaoqiang Ding、Andrey Kukharenko、Evgeny Izumchenko、Alex Zhavoronkov

作者机构

• Insilico Medicine Shanghai Ltd., Shanghai, China.
• Insilico Medicine AI Limited, Abu Dhabi, UAE.
• Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong SAR, China.
• Department of Clinical Pharmacology, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, China.
• Insilico Medicine US Inc., New York, NY, USA.
• Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Aachen, Germany.
• Department of Nephrology, University Clinic RWTH Aachen, Aachen, Germany.
• Insilico Medicine Canada Inc, Montreal, Quebec, Canada.
• Department of Cancer and Cellular Biology, Lewis Katz School of Medicine, Temple University, PA, USA.
• Division of Nephrology, Zhongshan Hospital Shanghai Medical College, Fudan University, Shanghai, China.
• Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
• Insilico Medicine AI Limited, Abu Dhabi, UAE. alex@insilico.com.
• Insilico Medicine Hong Kong Ltd., Hong Kong Science and Technology Park, Hong Kong SAR, China. alex@insilico.com.
• Insilico Medicine US Inc., New York, NY, USA. alex@insilico.com.
• Insilico Medicine Canada Inc, Montreal, Quebec, Canada. alex@insilico.com.

技术路线

AI预测靶点→AI驱动生成小分子INS018_055→体内外抗纤维化/抗炎活性评估→随机双盲安慰剂对照I期临床试验（NCT05154240，78名健康受试者）安全性/耐受性/药代动力学验证→中国I期试验（CTR20221542）验证安全性/药代动力学

最近 5 个完整年度引用趋势

完整作者

David Ochoa、Andrew Hercules、Miguel Carmona、Daniel Suveges、Jarrod Baker、Cinzia Malangone、Irene Lopez、Alfredo Miranda、Carlos Cruz-Castillo、Luca Fumis、Manuel Bernal-Llinares、Kirill Tsukanov、Helena Cornu、Konstantinos Tsirigos、Olesya Razuvayevskaya、Annalisa Buniello、Jeremy Schwartzentruber、Mohd Karim、Bruno Ariano、Ricardo Esteban Martinez Osorio、Javier Ferrer、Xiangyu Ge、Sandra Machlitt-Northen、Asier Gonzalez-Uriarte、Shyamasree Saha、Santosh Tirunagari、Chintan Mehta、Juan María Roldán-Romero、Stuart Horswell、Sarah Young、Maya Ghoussaini、David G Hulcoop、Ian Dunham、Ellen M McDonagh

作者机构

• Open Targets, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
• European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
• Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.
• GlaxoSmithKline plc, GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, SG1 2NY, UK.

技术路线

公开数据 → 数据集成与统一

最近 5 个完整年度引用趋势