Simultaneous derivation, validation, and comparison of predictor hazard ratios for cardiovascular risk prediction equations in patients with diabetes from high versus non-high income countries: cohort study.
Section of Epidemiology and Biostatistics, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Department of Chronic Diseases and Health Promotion, Yinzhou District Centre for Disease Control and Prevention, Ningbo, China.
Department of General Practice and Primary Health Care, School of Population Health, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Department of Medicine, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Ngāi Tahu Māori Health Research Unit, Division of Health Sciences, University of Otago, Dunedin, New Zealand.
Key Laboratory of Epidemiology of Major Diseases (Peking University), Ministry of Education, Beijing, China.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China peigao@bjmu.edu.cn.
Peking University Clinical Research Institute, Peking University, Beijing, China.
Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Department of Gastric Surgery, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong, China.
Department of Pathology, Jiangmen Central Hospital, Jiangmen, China.
Department of Pathology, Zhongshan People's Hospital, Zhongshan, China.
Department of Pathology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China.
Department of Pathology, The Tenth Affiliated Hospital, Southern Medical University, Dongguan People's Hospital, Dongguan, China.
Department of Pathology, Huizhou Central People's Hospital, Huizhou, China.
Department of Pathology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong, China. jhc@ust.hk.
Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Hong Kong, China. jhc@ust.hk.
Division of Life Science, Hong Kong University of Science and Technology, Hong Kong, China. jhc@ust.hk.
HKUST Shenzhen-Hong Kong Collaborative Innovation Research Institute, Futian, Shenzhen, China. jhc@ust.hk.
State Key Laboratory of Nervous System Disorders, The Hong Kong University of Science and Technology, Hong Kong, China. jhc@ust.hk.
SIAT-HKUST Joint Laboratory for Brain Science, The Hong Kong University of Science and Technology, Hong Kong, China. jhc@ust.hk.
Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China. caimy@sysucc.org.cn.
Sian Liu、Wenxin Zheng、Jin Kang、Tianyi Xu、Siming Chen、Gen Li、Junlong Li、Hang Wong、Meihao Wang、Xiaokai Bai、Changxi Hu、Cheng Tang、Shengwei Jin、Zixing Zou、Ieng Chong、Yuxing Lu、Io Nam Wong、Hui Xu、Charlotte L Zhang、Jingman Shi、Erhu Feng、Jinyu Gu、Zhuo Sun、Haibo Chen、Li Yang、Yuan Zhang、Xian Zhu、Huanhuan Huang、Xiuyuan Xu、Xue Li、Zhenhui Zhao、Hongbo Qi、Xinyu Lu、Ngaman Cheng、Sicheng Pan、Ning Sun、Yun Yin、Michelle Williams、Eric Oermann、John E J Rasko、Jin Li、Kai Wang、Kang Zhang、Hao Wu、Yubin Xia、Fanxin Zeng、International Consortium of Digital Twins in Healthcare and Medicine
作者机构
Center for Big Data and Intelligent Medicine, The First Affiliated Hospital of Chongqing Medical University; Key Laboratory of Digital Health and Intelligent Medicine, Chongqing Municipal Health Commission and Chongqing Translational Medicine Center, Chongqing, China.
State Key Lab of Eye Health and Clinical Data Science Institute, Institute for Advanced Study on Eye Health and Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Department of Computer Science, Shanghai Jiao Tong University, Shanghai, China.
Artificial Intelligence Cross Disciplinary Research Institute and Faculty of Medicine, Macau University of Science and Technology, Macau, China.
Department of Radiology, Department of Anesthesia and Critical Care, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, China.
Guangzhou National Laboratory, Guangzhou, China.
Department of Big Data and Biomedical AI, College of Future Technology, Peking University, Beijing, China.
College of Computer Science, Sichuan University, Chengdu, China.
Department of Clinical Research Center, Dazhou Central Hospital and Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Dazhou, China.
Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Baichuan Inc., Beijing, China.
Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Departments of Neurosurgery, Radiology and Data Science, Neuroscience Institute, NYU Langone Medical Center, New York University, New York, NY, USA.
Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.
College of Life Science, Fudan University, Shanghai, China. li_jin_lifescience@fudan.edu.cn.
Artificial Intelligence Cross Disciplinary Research Institute and Faculty of Medicine, Macau University of Science and Technology, Macau, China. kaiwang314@gmail.com.
State Key Lab of Eye Health and Clinical Data Science Institute, Institute for Advanced Study on Eye Health and Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China. kang.zhang@gmail.com.
Artificial Intelligence Cross Disciplinary Research Institute and Faculty of Medicine, Macau University of Science and Technology, Macau, China. kang.zhang@gmail.com.
Guangzhou National Laboratory, Guangzhou, China. kang.zhang@gmail.com.
Center for Big Data and Intelligent Medicine, The First Affiliated Hospital of Chongqing Medical University; Key Laboratory of Digital Health and Intelligent Medicine, Chongqing Municipal Health Commission and Chongqing Translational Medicine Center, Chongqing, China. wuhao@cqmu.edu.cn.
Department of Computer Science, Shanghai Jiao Tong University, Shanghai, China. xiayubin@sjtu.edu.cn.
Department of Clinical Research Center, Dazhou Central Hospital and Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Dazhou, China. zengfx@pku.edu.cn.
Philip M Croon、Bruno Batinica、Lovedeep S Dhingra、Ryan B Choi、Evangelos K Oikonomou、Sumukh V Shankar、Veer Sangha、Robert M A van der Boon、Michelle Michels、Maarten van Ettinger、Peter-Paul Zwetsloot、Sergio Teruya、Cesia Gallegos Kattan、Edward J Miller、Navid Noory、Oscar M Westin、Sie K Fensman、Steen Hvitfeldt Poulsen、Avneet Singh、Sudarshan Balla、Anouk Achten、Charalambos Vlachopoulos、Alexios S Antonopoulos、Nico Bruining、Julian D Gillmore、Mathew S Maurer、Frederick L Ruberg、Marianna Fontana、Rohan Khera
作者机构
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Cardiovascular Data Science (CarDS) Lab, Yale School of Medicine, New Haven, Connecticut.
Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Thoraxcenter, Cardiovascular Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Division of Cardiology, Columbia University Irving Medical Center, New York, New York.
Heart Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Department of Cardiology, Northwell Health, New York, New York.
Department of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown.
Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, the Netherlands.
National Amyloidosis Centre, University College London, Royal Free Hospital, London, United Kingdom.
Cardiogenetics Unit, First Department of Cardiology, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece.
Section of Cardiovascular Medicine and Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, Massachusetts.
Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut.
Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, Connecticut.
Section of Health Informatics, Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut.
Ximing Ran、Joanne Wuu、Zhaohui S Qin、Michael P McDermott、Johnathan Cooper-Knock、Yindi Li、Volkan Granit、Anne-Laure Grignon、Elizabeth Lin、Maria Catalina Fernandez、Danielle Colato、Nathan Carberry、Christina M Lill、Paolo Piazza、Andrea Malaspina、Michael Benatar
作者机构
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
Department of Computer Science, Emory University, Atlanta, GA, USA.
Department of Neurology and ALS Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
NIHR Sheffield Biomedical Research Centre, Sheffield, UK.
Department of Neuromuscular Diseases, UCL Queen Square Motor Neuron Disease Center, UCL Queen Square Institute of Neurology, University College London, London, UK.
Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Ageing and Epidemiology Unit (AGE), School of Public Health, Imperial College London, London, UK.
Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.
Department of Neurology and ALS Center, University of Miami Miller School of Medicine, Miami, FL, USA. mbenatar@med.miami.edu.
为什么值得关注
编辑短评高收入国家开发的糖尿病心血管风险评分直接在其他国家使用时，仅靠简单重校准不够；年龄的风险效应在人群间差异很大，更新年龄这类关键预测因子的 HR，才能显著改善风险标定。