洞察前沿，连接科研新知

完整作者

Qinhao Cao、Jared E Toettcher

作者机构

• Department of Molecular Biology, Princeton University, Princeton, NJ, USA.
• Department of Molecular Biology, Princeton University, Princeton, NJ, USA. toettcher@princeton.edu.
• Omenn-Darling Bioengineering Institute, Princeton University, Princeton, NJ, USA. toettcher@princeton.edu.

技术路线

已表征的变构Gal4转录因子与经典激酶FRET生物传感器架构（作为设计起点） → 构建并优化磷酸化控制开关（phospho-switch）各特征，获得ERK控制的转录因子

最近 5 个完整年度引用趋势

完整作者

Fabian Streit、Swapnil Awasthi、Alisha S M Hall、Alice Braun、Maria Niarchou、Eirini Marouli、Oladapo Babajide、Josef Frank、Lea Zillich、Carolin M Callies、Diana Avetyan、Eric Zillich、Joonas Naamanka、Jean Gonzalez、Arvid Harder、Yi Lu、Zouhair Aherrahrou、Zain-Ul-Abideen Ahmad、Helga Ask、Anthony Batzler、Michael E Benros、Odette M Brand-de Wilde、Søren Brunak、Mie T Bruun、Lea A N Christoffersen、Lucía Colodro-Conde、Brandon J Coombes、Elizabeth C Corfield、Norbert Dahmen、Maria Didriksen、Khoa M Dinh、Srdjan Djurovic、Joseph Dowsett、Ole Kristian Drange、Helene Dukal、Susanne Edelmann、Christian Erikstrup、Mariana K Espinola、Eva Fassbinder、Annika Faucon、Diana S Ferreira de Sá、Jerome C Foo、Maria Gilles、Alfonso Gutiérrez-Zotes、Thomas F Hansen、Magnus Haraldsson、R Patrick Harper、Alexandra Havdahl、Urs Heilbronner、Stefan Herms、Henrik Hjalgrim、Christopher Hübel、Gitta A Jacob、Bitten Aagaard、Anders Jorgensen、Martin Jungkunz、Nikolaus Kleindienst、Nora Knoblich、Stefanie Koglin、Julia Kraft、Kristi Krebs、Christopher W Lee、Yuhao Lin、Stefanie Lis、Amanda Lisoway、Ioannis A Malogiannis、Amy Martinsen、Tolou Maslahati、Katharina Merz、Andreas Meyer-Lindenberg、Susan Mikkelsen、Christina Mikkelsen、Arian Mobascher、Gerard Muntané、Asmundur Oddsson、Sisse R Ostrowski、Teemu Palviainen、Ole B V Pedersen、Geir Pedersen、Liam Quinn、Matthias A Reinhard、Florian A Ruths、Björn H Schott、Michael Schredl、Emanuel Schwarz、Cornelia E Schwarze、Michael Schwinn、Tabea Sarah Send、Engilbert Sigurdsson、Katja Simon-Keller、Astros T Skuladottir、Joaquim Soler、Anne Sonley、Erik Sørensen、Hreinn Stefansson、Peter Straub、Jaana Suvisaari、Martin Tesli、Jacob Træholt、Henrik Ullum、Maja P Völker、G Bragi Walters、Rujia Wang、Christian C Witt、Gerhard Zarbock、Peter Zill、John-Anker Zwart、DBDS Genomic Consortium、GLAD Study、HUNT All-In Psychiatry、Ole A Andreassen、Arnoud Arntz、Joanna M Biernacka、Martin Bohus、Gerome Breen、Alexander L Chapman、Sven Cichon、Lea K Davis、Michael Deuschle、Sebastian Euler、Sabine C Herpertz、Benjamin Hummelen、Andrea Jobst、Jaakko Kaprio、James L Kennedy、Kelli Lehto、Klaus Lieb、Lourdes Martorell、Shelley McMain、Richard Musil、Vanessa Nieratschker、Markus M Nöthen、Frank Padberg、Aarno Palotie、Juan C Pascual、Nader Perroud、Josep A Ramos-Quiroga、Ted Reichborn-Kjennerud、Marta Ribases、Stefan Roepke、Dan Rujescu、Sandra Sanchez-Roige、Claudia Schilling、Christian Schmahl、Kari Stefansson、Thorgeir E Thorgeirsson、Gustavo Turecki、Elisabet Vilella、Thomas Werge、Bendik S Winsvold、Johannes Wrege、Marcella Rietschel、Stephan Ripke、Stephanie H Witt

作者机构

• Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. fabian.streit@zi-mannheim.de.
• Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. fabian.streit@zi-mannheim.de.
• Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. fabian.streit@zi-mannheim.de.
• German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim-Heidelberg-Ulm, Germany. fabian.streit@zi-mannheim.de.
• Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
• Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
• Department of Affective Disorders, Aarhus University Hospital-Psychiatry, Aarhus, Denmark.
• Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
• William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University London, London, UK.
• Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
• German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim-Heidelberg-Ulm, Germany.
• Hector Institute for Translational Brain Research, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
• Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
• Health Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
• Hector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
• Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
• SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
• Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
• Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
• Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany.
• DZHK (German Research Centre for Cardiovascular Research), partner site Hamburg/Lübeck/Kiel, Lübeck, Germany.
• University Heart Center Lübeck, Lübeck, Germany.
• Social, Genetic and Developmental Psychiatry Centre, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, UK.
• PsychGen Centre for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
• Department of Child Health and Development, Norwegian Institute of Public Health, Oslo, Norway.
• PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
• Department of Quantitative Health Sciences, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.
• Copenhagen Research Centre for Biological and Precision Psychiatry, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
• Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• Netherlands Institute for Personality Disorders, Halsteren, Netherlands.
• Department of Public Health & Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• Clinical Immunology Research Unit, Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
• Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark.
• Institute of Biological Psychiatry, Mental Health Services, University of Copenhagen, Copenhagen, Denmark.
• Brain and Mental Health Research Program, QIMR Berghofer, Brisbane, Queensland, Australia.
• School of Psychology, The University of Queensland, Brisbane, Queensland, Australia.
• Psychiatric Genetic Epidemiology Group, Research Department & Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
• MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
• Department of Psychiatry and Psychotherapy, University Medical Center, University of Mainz, Mainz, Germany.
• Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
• Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
• Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
• Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
• Department of Psychiatry, Sørlandet Hospital, Kristiansand, Agder, Norway.
• Department of Psychiatry and Psychotherapy, University Hospital Tübingen, Tübingen, Germany.
• German Center for Mental Health (DZPG), partner site Tübingen, Tübingen, Germany.
• Department of Psychiatry and Psychotherapy, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
• Department of Psychology, Division of Clinical Psychology and Psychotherapy, Saarland University, Saarbrücken, Germany.
• Institute for Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
• Department of Psychiatry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada.
• Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada.
• Hospital Universitari Institut Pere Mata (HUIPM), Institute de Recerca Biomédica Catalunya Sud (IRB-CatSud) previously IISPV-CERCA, Universitat Rovira i Virgili (URV), Reus, Spain.
• Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain.
• Neurogenomic, Translational Research Centre, Copenhagen University Hospital, Glostrup, Denmark.
• Danish Headache Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
• Landspitali University Hospital, Reykjavik, Iceland.
• Faculty of Medicine, Department of Psychiatry, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
• Bradford District Care NHS Foundation Trust, Bradford, UK.
• Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany.
• Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
• Institute of Human Genetics, University Hospital Bonn & University of Bonn, Bonn, Germany.
• Danish Cancer Institute, Copenhagen, Denmark.
• Department of Haematology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
• UK National Institute for Health Research (NIHR) Biomedical Research Centre, South London and Maudsley Hospital and King's College London, London, UK.
• National Centre for Register-based Research, Aarhus University, Aarhus, Denmark.
• Clinic for Child and Adolescent Psychiatry, German Red Cross Hospitals Westend, Berlin, Germany.
• Institute for Psychology, Department of Clinical Psychology and Psychotherapy, University of Freiburg, Freiburg, Germany.
• Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.
• Psychiatric Center Copenhagen, Copenhagen, Denmark.
• Institute for Medical and Data Ethics, Heidelberg University, Faculty of Medicine, Heidelberg, Germany.
• German Cancer Research Center (DKFZ), Heidelberg, Germany.
• Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
• Department of Psychiatry and Neurosciences, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany.
• Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
• Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia.
• Department of Clinical Psychology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
• Molecular Brain Science, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
• Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
• First Department of Psychiatry, Eginition Hospital Medical School, National and Kapodistrian University of Athens, Athens, Greece.
• Department of Research and Innovation, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
• Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
• HUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
• Department of Psychiatry and Psychotherapy, LMU University Hospital Munich, Ludwig Maximilian University Munich, Munich, Germany.
• Institut de Biologia Evolutiva (UPF-CSIC), Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain.
• deCODE genetics / AMGEN, Reykjavik, Iceland.
• Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
• Department of Research and Innovation, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
• Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
• German Center for Mental Health (DZPG), Partner Site Munich-Augsburg, Munich-Augsburg, Germany.
• South London and Maudsley NHS Foundation Trust, London, UK.
• Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
• German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
• Leibniz Institute for Neurobiology, Magdeburg, Germany.
• Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany.
• Department of Psychiatry and Psychotherapy, Sleep Laboratory, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
• Department of Clinical Psychology and Psychotherapy, Charlotte Fresenius University, Wiesbaden, Germany.
• Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
• Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Institut de Recerca Biomèdica Sant Pau (IIB-Sant Pau), Barcelona, Spain.
• Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
• Department of Psychiatry and Forensic Medicine & Institute of Neurosciences, Universitat Autònoma de Barcelona, Bellaterra, Spain.
• Borderline Personality Disorder Clinic, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
• Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
• Finnish Institute for Health and Welfare (THL), Helsinki, Finland.
• Mental health and suicide, Norwegian Institute of Public Health, Oslo, Norway.
• Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
• Statens Serum Institut, Copenhagen, Denmark.
• Department of Anaesthesiology and Operative Intensive Care, University Hospital Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
• IVAH, Institut für Verhaltenstherapie-Ausbildung Hamburg, gemeinnützige GmbH, Hamburg, Germany.
• KG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.
• Department of Clinical Psychology, University of Amsterdam, Amsterdam, the Netherlands.
• Department of Psychiatry & Psychology, Division of Computational Biology, Mayo Clinic, Rochester, MN, USA.
• Department of Psychology, Faculty of Arts and Social Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.
• DBT Centre of Vancouver, Vancouver, British Columbia, Canada.
• Department of Biomedicine, University of Basel, Basel, Switzerland.
• Medical Genetics, Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland.
• Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany.
• Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
• Department of Consultation Psychiatry and Psychosomatics, University Hospital Zurich, Zurich, Switzerland.
• Department of General Psychiatry, University Hospital Heidelberg, Heidelberg University, Heidelberg, Germany.
• Borderline Personality Disorder Clinic, General Adult Psychiatry and Health Systems Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
• Oberberg Fachkliniken for Psychiatry, Psychosomatics and Psychotherapy, Bad Tölz, Germany.
• Insitute of Human Genetics, University Hospital Bonn & University of Bonn, Bonn, Germany.
• Analytic and Translational Genetics Unit, Department of Medicine, Department of Neurology and Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
• The Stanley Center for Psychiatric Research and Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Mental Health and Psychiatry Department, Vic Hospital Consortium, Vic, Spain.
• Department of Psychiatric, University Hospitals of Geneva, Geneva, Switzerland.
• Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
• Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
• Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
• Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
• Department of Genetics, Microbiology, and Statistics, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain.
• Department of Psychiatry, Oberberg Fachkliniken for Psychiatry, Psychosomatics and Psychotherapy, Wendisch Rietz, Germany.
• Department of Psychiatry, University of Halle, Halle, Germany.
• Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.
• Douglas Institute, Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
• Department of Neurology, Oslo University Hospital, Oslo, Norway.
• Medical Faculty, University of Basel, Basel, Switzerland.
• Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
• Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. stephanie.witt@zi-mannheim.de.
• German Center for Mental Health (DZPG), Partner Site Mannheim-Heidelberg-Ulm, Mannheim-Heidelberg-Ulm, Germany. stephanie.witt@zi-mannheim.de.

技术路线

12,339例病例与1,041,717例对照的发现样本及685例病例与107,750例对照的重复样本（均为欧洲 ancestry）→GWAS荟萃分析（识别11个独立位点、9个基于基因分析的风险基因、SNP遗传力17.3%、构建多基因评分PGS，解释4.6%的责任尺度表型方差）→在Vanderbilt大学医学中心Biobank和UK Biobank中进行PGS的表型组关联分析验证

最近 5 个完整年度引用趋势

完整作者

Taotao Tan、Alejandra Vergara-Lope、José Jaime Martínez-Magaña、Nirav N Shah、Yi-Sian Lin、Kai Yuan、Jaime Berumen、Jesus Alegre-Díaz、Pablo Kuri-Morales、Roberto Tapia-Conyer、Joel Gelenter、Janitza L Montalvo-Ortiz、Wei Zhou、Jason M Torres、Elizabeth G Atkinson

作者机构

• Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
• Department of Integrative Physiology, Baylor College of Medicine, Houston, TX, USA.
• Clinical Trial Service Unit and Epidemiological Studies Unit, Oxford Population Health, Big Data Institute, University of Oxford, Oxford, UK.
• Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
• VA Connecticut Healthcare System, West Haven, CT, USA.
• Clinical Neurosciences Division, US Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, West Haven, CT, USA.
• Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
• Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Department of Medicine, Harvard Medical School, Boston, MA, USA.
• Experimental Research Unit, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
• Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
• Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Mexico.
• Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
• Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Elizabeth.Atkinson@bcm.edu.
• Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA. Elizabeth.Atkinson@bcm.edu.

技术路线

混合作战样本（UK Biobank、Yale-Penn队列、墨西哥城前瞻性研究） → Tractor-Mix关联分析（考虑亲缘关系与局部祖先）

最近 5 个完整年度引用趋势

完整作者

Yaokun Liang、Xianghui Qi、Song Gao、Yunjiao Wang、Guoshi Kan、Leonid N Valentovich、Jingjing Guo、Yingfeng An

作者机构

• College of Biosciences and Biotechnology, Shenyang Agricultural University, Shenyang 110866, Liaoning, China.
• Shenyang Key Laboratory of Microbial Resource Mining and Molecular Breeding, Liaoning 110000, Shenyang, China.
• School of Life Sciences, Guangzhou University, Guangzhou, Guangdong 510006, China.
• Institute of Microbiology, National Academy of Sciences of Belarus, Minsk 220000, Belarus.
• Engineering Research Centre of Applied Technology on Machine Translation and Artificial Intelligence, Macao Polytechnic University, Macau 999078, China.

技术路线

以荧光蛋白为报告基因→基于光敏CRISPR/dCas9系统，整合翻译与翻译后水平的调控模式，对dCas9蛋白实施多层级精准调控，分析目标基因转录水平变化（mCherry荧光强度较无调控提升最高2.58倍）

最近 5 个完整年度引用趋势

完整作者

Shangtao Wang、Jinling Zhang、Wenshuang Wang、Sihan Xu、Man Zhang、Yuanyuan Hou、Gang Bai

作者机构

• College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300350, China.

技术路线

暂未整理

最近 5 个完整年度引用趋势

完整作者

Peter Orchard、Thomas W Blackwell、Linda Kachuri、Peter J Castaldi、Michael H Cho、Stephanie A Christenson、Peter Durda、Stacey Gabriel、Craig P Hersh、Scott Huntsman、Seungyong Hwang、Roby Joehanes、Mari Johnson、Xingnan Li、Honghuang Lin、Ching-Ti Liu、Yongmei Liu、Angel C Y Mak、Ani W Manichaikul、David T Paik、Aabida Saferali、Joshua D Smith、Kent D Taylor、Russell P Tracy、Jiongming Wang、Mingqiang Wang、Joshua S Weinstock、Jeffrey Weiss、Heather E Wheeler、Ying Zhou、Sebastian Zöllner、Joseph C Wu、Luisa Mestroni、Sharon Graw、Matthew R G Taylor、Victor E Ortega、W Craig Johnson、Weiniu Gan、Goncalo Abecasis、Deborah A Nickerson、Namrata Gupta、Kristin Ardlie、Prescott G Woodruff、Russell P Bowler、Deborah A Meyers、Alex Reiner、Charles Kooperberg、Elad Ziv、Ramachandran S Vasan、Martin G Larson、L Adrienne Cupples、Edwin K Silverman、Stephen S Rich、Nancy Heard-Costa、Hua Tang、Jerome I Rotter、Albert V Smith、Daniel Levy、NHLBI TOPMed Consortium Multi-Omics Working Group32、NHLBI TOPMed Consortium32§、François Aguet、Laura J Scott、Laura M Raffield、Stephen C J Parker、Namiko Abe、Laura Almasy、Seth Ament、Pramod Anugu、Paul Auer、Dimitrios Avramopoulos、Adithya Balasubramanian、R Graham Barr、Lucas Barwick、Terri Beaty、Diane Becker、Lewis Becker、Amber Beitelshees、Takis Benos、Marcos Bezerra、Joshua Bis、Jennifer Brody、Ulrich Broeckel、Jai Broome、Karen Bunting、Erin Buth、Vincent Carey、Cara Carty、Richard Casaburi、Mark Chaffin、Christy Chang、Yi-Cheng Chang、Sameer Chavan、Bo-Juen Chen、Wei-Min Chen、Seung Hoan Choi、Lee-Ming Chuang、Ren-Hua Chung、Matthew Conomos、Elaine Cornell、Carolyn Crandall、James Crapo、Jeffrey Curtis、Coleen Damcott、Sean David、Lisa de Las Fuentes、Paul de Vries、Ranjan Deka、Dawn DeMeo、Scott Devine、Huyen Dinh、Harsha Doddapaneni、Qing Duan、Ravi Duggirala、Charles Eaton、Lynette Ekunwe、Adel El Boueiz、Leslie Emery、Charles Farber、Jesse Farek、Nora Franceschini、Chris Frazar、Mao Fu、Stephanie M Fullerton、Lucinda Fulton、Shanshan Gao、Yan Gao、Margery Gass、Heather Geiger、Auyon Ghosh、Chris Gignoux、David Glahn、Stephanie Gogarten、Da-Wei Gong、Harald Goring、Daniel Grine、C Charles Gu、Yue Guan、Michael Hall、Yi Han、Daniel Harris、Ben Heavner、David Herrington、Brian Hobbs、Elliott Hong、Karin Hoth、Chao Agnes Hsiung、Jianhong Hu、Yi-Jen Hung、Haley Huston、Chii Min Hwu、Rebecca Jackson、Deepti Jain、Jill Johnsen、Rich Johnston、Kimberly Jones、Michael Kessler、Alyna Khan、Ziad Khan、Wonji Kim、John Kimoff、Greg Kinney、Holly Kramer、Christoph Lange、Ethan Lange、Cathy Laurie、Cecelia Laurie、Meryl LeBoff、Sandra Lee、Wen-Jane Lee、David Levine、Joshua Lewis、Yun Li、Xihong Lin、Simin Liu、Yu Liu、Barry Make、Alisa Manning、JoAnn Manson、Lisa Martin、Melissa Marton、Susan Mathai、Susanne May、Patrick McArdle、Merry-Lynn McDonald、Sean McFarland、Daniel McGoldrick、Caitlin McHugh、Hao Mei、James Meigs、Vipin Menon、Nancy Min、Matt Moll、Zeineen Momin、May Montasser、Josyf C Mychaleckyj、Rakhi Naik、Take Naseri、Pradeep Natarajan、Sarah C Nelson、Bonnie Neltner、Caitlin Nessner、Osuji Nkechinyere、Jeff O'Connell、Tim O'Connor、Heather Ochs-Balcom、Geoffrey Okwuonu、James Pankow、Cora Parker、Gina Peloso、Juan Manuel Peralta、Marco Perez、James Perry、Ulrike Peters、Lawrence S Phillips、Toni Pollin、Julia Powers Becker、Meher Preethi Boorgula、Bruce Psaty、Dandi Qiao、Nicholas Rafaels、Mahitha Rajendran、Laura Rasmussen-Torvik、Aakrosh Ratan、Robert Reed、Elizabeth Regan、Muagututi'a Sefuiva Reupena、Rebecca Robillard、Carolina Roselli、Ingo Ruczinski、Alexi Runnels、Pamela Russell、Kathleen Ryan、Ester Cerdeira Sabino、Shabnam Salimi、Sejal Salvi、Steven Salzberg、Kevin Sandow、Jireh Santibanez、Karen Schwander、Frank Sciurba、Frédéric Sériès、Amol Shetty、Aniket Shetty、Brian Silver、Robert Skomro、Tanja Smith、Sylvia Smoller、Beverly Snively、Adrienne M Stilp、Garrett Storm、Elizabeth Streeten、Jessica Lasky Su、Yun Ju Sung、Jody Sylvia、Adam Szpiro、Margaret Taub、Simeon Taylor、Timothy A Thornton、Machiko Threlkeld、Lesley Tinker、David Tirschwell、Hemant Tiwari、Catherine Tong、Michael Tsai、Dhananjay Vaidya、Tarik Walker、Robert Wallace、Avram Walts、Fei Fei Wang、Heming Wang、Karol Watson、Jennifer Watt、Lu-Chen Weng、Jennifer Wessel、Kayleen Williams、Carla Wilson、James Wilson、Lara Winterkorn、Quenna Wong、Baojun Wu、Huichun Xu、Lisa Yanek、Ivana Yang、Seyedeh Maryam Zekavat、Snow Xueyan Zhao、Wei Zhao、Xiaofeng Zhu

作者机构

• Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
• Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
• Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
• Department of Epidemiology and Population Health, School of Medicine, Stanford University, Stanford, CA, USA.
• Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
• Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
• Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
• Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
• Department of Genetics, Stanford University, Stanford, CA, USA.
• Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
• Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health and Boston University, Framingham, MA, USA.
• Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
• Division of Data Driven and Digital Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
• Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
• Department of Biostatistics, School of Public Health, Boston University, Boston, MA, USA.
• Division of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, USA.
• Department of Genome Sciences, School of Medicine, University of Virginia, Charlottesville, VA, USA.
• Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.
• Northwest Genomics Center, University of Washington, Seattle, WA, USA.
• The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
• Laboratory for Clinical Biochemistry Research, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
• Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
• Program in Bioinformatics, Loyola University Chicago, Chicago, IL, USA.
• Department of Biology, Loyola University Chicago, Chicago, IL, USA.
• Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
• Department of Medicine, Adult Medical Genetics Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
• Department of Medicine, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Phoenix, AZ, USA.
• Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA, USA.
• National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
• Department of Genome Sciences, University of Washington, Seattle, WA, USA.
• Cardiovascular Research Institute, University of California, San Francisco; San Francisco, CA, USA.
• Department of Genomic Sciences and Systems Biology, Cleveland Clinic, Cleveland, OH, USA.
• Department of Medicine, Mayo Clinic, Scottsdale, AZ, USA.
• Department of Epidemiology, University of Washington, Seattle, WA, USA.
• Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
• Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.
• Department of Medicine, School of Medicine, Boston University, Boston, MA, USA.
• Chobanian & Avedisian School of Medicine, Boston University, Boston, MA, USA.
• Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
• Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
• New York Genome Center, New York, NY, USA.
• Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
• University of Maryland, Baltimore, MD, USA.
• University of Mississippi, Jackson, MS, USA.
• Medical College of Wisconsin, Milwaukee, WI, USA.
• Johns Hopkins University, Baltimore, MD, USA.
• Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA.
• Columbia University, New York, NY, USA.
• The Emmes Corporation, Rockville, MD, USA.
• University of Pittsburgh, Pittsburgh, PA, USA.
• Fundação de Hematologia e Hemoterapia de Pernambuco - Hemope, Recife, Brazil.
• University of Washington, Seattle, WA, USA.
• Brigham andWomen's Hospital, Boston, MA, USA.
• Washington State University, Pullman, WA, USA.
• University of California, Los Angeles, Los Angeles, CA, USA.
• Broad Institute, Cambridge, MA, USA.
• National Taiwan University, Taipei, Taiwan (Province of China).
• University of Colorado at Denver, Denver, CO, USA.
• University of Virginia, Charlottesville, VA, USA.
• National Health Research Institute Taiwan, Miaoli County, Taiwan (Province of China).
• University of Vermont, Burlington, VT, USA.
• National Jewish Health, Denver, CO, USA.
• University of Michigan, Ann Arbor, MI, USA.
• University of Chicago, Chicago, IL, USA.
• Washington University in St. Louis, St. Louis, MO, USA.
• University of Texas Health at Houston, Houston, TX, USA.
• University of Cincinnati, Cincinnati, OH, USA.
• University of North Carolina, Chapel Hill, NC, USA.
• University of Texas Rio Grande Valley School of Medicine, Edinburg, TX, USA.
• Harvard University, Cambridge, MA, USA.
• Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
• New York Genome Center, New York City, NY, USA.
• Stanford University, Stanford, CA, USA.
• Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
• University of Texas Rio Grande Valley School of Medicine, San Antonio, TX, USA.
• University of Maryland, Philadelphia, PA, USA.
• Wake Forest Baptist Health, Winston-Salem, NC, USA.
• University of Iowa, Iowa City, IA.
• Tri-Service General Hospital National Defense Medical Center, Taiwan (Province of China).
• Blood Works Northwest, Seattle, WA, USA.
• Taichung Veterans General Hospital Taiwan, Taichung City, Taiwan (Province of China).
• Oklahoma State University Medical Center, Columbus, OH, USA.
• Emory University, Atlanta, GA, USA.
• McGill University, Montréal, QC, Canada.
• University of Colorado at Denver, Aurora, CO, USA.
• Loyola University, Maywood, IL, USA.
• Harvard School of Public Health, Boston, MA, USA.
• Brown University, Providence, RI, USA.
• Broad Institute, Harvard University, Massachusetts General Hospital, Boston, MA, USA.
• George Washington University, Washington, DC, USA.
• University of Alabama, Birmingham, AL, USA.
• Massachusetts General Hospital, Boston, MA, USA.
• National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
• Ministry of Health, Government of Samoa, Apia, Samoa.
• University at Buffalo, Buffalo, NY, USA.
• University of Minnesota, Minneapolis, MN, USA.
• RTI International, Research Triangle Park, NC, USA.
• Boston University, Boston, MA, USA.
• Northwestern University, Chicago, IL, USA.
• Lutia I Puava Ae Mapu I Fagalele, Apia, Samoa.
• University of Ottawa, Ottawa, ON, Canada.
• Universidade de Sao Paulo, Sao Paulo, Brazil.
• University of Maryland, Seattle, WA, USA.
• Lundquist Institute, Torrance, CA, USA.
• Université Laval, Quebec City, Canada.
• UMass Memorial Medical Center, Worcester, MA, USA.
• University of Saskatchewan, Saskatoon, Canada.
• Albert Einstein College of Medicine, New York, NY, USA.
• Brigham and Women's Hospital, Mass General Brigham, Boston, MA, USA.
• Indiana University, Indianapolis, IN, USA.
• Beth Israel Deaconess Medical Center, Cambridge, MA, USA.
• Henry Ford Health System, Detroit, MI, USA.
• Case Western Reserve University, Cleveland, OH, USA.

技术路线

14,324份TOPMed RNA测序样本 → 六种组织/细胞类型的cis-eQTL与sQTL分析，检测次级cis-e/sQTL并精细定位

最近 5 个完整年度引用趋势

完整作者

暂未整理

作者机构

暂未整理

技术路线

暂未整理

最近 5 个完整年度引用趋势

完整作者

暂未整理

作者机构

暂未整理

技术路线

暂未整理

最近 5 个完整年度引用趋势

暂无引用数据

完整作者

Yuta Yamagishi、Yoshiki Sonoyama、Naoki Kawakami、Tomonori Hasebe、Masayuki Su'etsugu

作者机构

• Department of Life Science, College of Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku, Tokyo 171-8501, Japan.

技术路线

53 kb环状DNA模块基因组（编码26个RCR蛋白）→在PURE无细胞体系中一锅表达并自我复制→优化反应条件与解决表达瓶颈后实现递归自我复制（>28次倍增）

最近 5 个完整年度引用趋势

完整作者

Liujia Qian、Zizhuo Zhou、Peijie Zhou、Zhen Dong、Xudong Zhang、Zhenwu Dai、Zhangyang Gao、Siqi Sun、Kevin R Roy、Shuaiyao Wang、Nicola Zamboni、Charles Boone、Michael Costanzo、Jianzhe Li、Gianni Liti、Jia-Xing Yue、Markus Ralser、Evan Williams、Mattia Zampieri、Heng Jiang、Tailin Wu、Yalin Wang、Feiran Li、Joseph Schacherer、Rui Sun、Zhaoxing Li、Yaming Deng、Yi Chen、Zhiping Xie、Huiqiang Lou、Xiaowen Wang、Linhai Xie、Han Wen、Liangyi Chen、Kai Lei、George Rosenberger、Xue Cai、Yingrui Wang、Qi Xiao、Huaizong Shen、Gaowen Liu、Lei Ma、Brenda Andrews、Hui Lu、Kiryl Piatkevich、Yi Zhu、Lei Bai、Yizhi Cai、Yuping Chen、Weinan E、Ge Gao、Fuchu He、Luonan Chen、Stan Z Li、Hongwu Ma、Liang Qiao、Lars M Steinmetz、Leihan Tang、Tang Tang、Xiaofan Zhang、Jing Yang、Yifan Yang、Kaicheng Yu、Jianyang Zeng、Yefeng Zheng、Bowen Zhou、Tiannan Guo

作者机构

• Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China.
• Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
• Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China.
• Center for Machine Learning Research, Peking University, Beijing, China.
• AI for Science Institute, Beijing, China.
• National Engineering Laboratory for Big Data Analysis and Applications, Beijing, China.
• Center for Data Science, Peking University, Beijing, China.
• Shanghai Artificial Intelligence Laboratory, Shanghai, China.
• Research Institute of Intelligent Complex Systems, Fudan University, Shanghai, China.
• Stanford Genome Technology Center, Stanford University, Palo Alto, CA, USA.
• Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
• Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
• The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
• Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
• Institute of Research on Cancer and Ageing of Nice (IRCAN), Faculté de Médecine, Nice, France.
• State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
• Department of Biochemistry, Charité-Universitätsmedizin Berlin, Berlin, Germany.
• Exploratory Diagnostic Sciences, Berlin Institute of Health at Charité, Berlin, Germany.
• Center for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
• Max Planck Institute for Molecular Genetics, Berlin, Germany.
• Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
• Department of Biomedicine, University of Basel, Basel, Switzerland.
• Department of Artificial Intelligence, School of Engineering, Westlake University, Hangzhou, China.
• Biomedical Research Core Facilities, Westlake University, Hangzhou, China.
• Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.
• Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104-UMR-S 1258, Illkirch, France.
• State Key Laboratory of Microbial Metabolism and Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
• South China Hospital, Health Science Center, Guangdong Key Laboratory of Genome Instability and Disease Prevention, Shenzhen University School of Medicine, Shenzhen, China.
• State Key Laboratory of Medical Proteomics, National Center for Protein Sciences (Beijing), Research Unit of Proteomics Driven Cancer Precision Medicine (Chinese Academy of Medical Sciences), Beijing, China.
• International Academy of Phronesis Medicine (Guangdong), Guangzhou, China.
• DP Technology Co. Ltd., Beijing, China.
• Beijing Advanced Center of RNA Biology (BEACON), Peking University, Beijing, China.
• State Key Laboratory of Medical Proteomics, Beijing, China.
• State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Center for Life Sciences, College of Future Technology, Peking University, Beijing, China.
• Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
• Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, China.
• Institute of Biology, Westlake Institute for Advanced Study, Hangzhou, China.
• Bruker Switzerland AG, Faellanden, Switzerland.
• Zhejiang Key Laboratory of Structural Biology, School of Life Sciences, Westlake University, Hangzhou, China.
• Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
• National Biomedical Imaging Center, College of Future Technology, Peking University, Beijing, China.
• State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
• SJTU-Yale Joint Center of Biostatistics and Data Science, National Center for Translational Medicine, MoE Key Lab of Artificial Intelligence, AI Institute Shanghai Jiao Tong University, Shanghai, China.
• Shanghai Engineering Research Center for Big Data in Pediatric Precision Medicine, NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology & Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China.
• School of Life Sciences, Westlake University, Hangzhou, China.
• Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, China.
• Manchester Institute of Biotechnology, University of Manchester, Manchester, UK.
• Generative and Synthetic Genomics, Wellcome Sanger Institute, Cambridge, UK.
• Shenzhen Institute of Synthetic Biology, Chinese Academy of Sciences, Shenzhen, China.
• Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
• School of Mathematical Sciences, Peking University, Beijing, China.
• State Key Laboratory of Gene Function and Modulation Research, Biomedical Pioneering Innovative Center (BIOPIC) and Beijing Advanced Innovation Center for Genomics (ICG), School of Life Sciences, Center for Bioinformatics (CBI), Peking University, Beijing, China.
• School of Mathematical Sciences and School of AI, Shanghai Jiao Tong University, Shanghai, China.
• AI Laboratory, Research Center for Industries of the Future, Westlake University, Hangzhou, China.
• Biodesign Center, State Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
• National Center of Technology Innovation for Synthetic Biology, Tianjin, China.
• Department of Chemistry, Fudan University, Shanghai, China.
• Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
• DZHK (German Centre for Cardiovascular Research), Heidelberg, Germany.
• Stanford Genome Technology Center, Palo Alto, CA, USA.
• Center for Interdisciplinary Studies, Westlake University, Hangzhou, China.
• Wuhan Metware Biotechnology Co. Ltd., Wuhan, China.
• Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, China.
• State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Lifeomics, Beijing, China.
• School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, China.
• Autolab, Westlake University, Hangzhou, China.
• School of Engineering, Research Center for Industries of the Future, Westlake University, Hangzhou, China.
• Medical Artificial Intelligence Laboratory, Westlake University, Hangzhou, China.
• Department of Electronic Engineering, Tsinghua University, Beijing, China.
• Affiliated Hangzhou First People's Hospital, State Key Laboratory of Medical Proteomics, School of Medicine, School of Future Biomedicine, Westlake University, Hangzhou, China. guotiannan@westlake.edu.cn.
• Westlake Center for Intelligent Proteomics, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. guotiannan@westlake.edu.cn.
• Research Center for Industries of the Future, School of Life Sciences, Westlake University, Hangzhou, China. guotiannan@westlake.edu.cn.

技术路线

多模态生物数据与机理知识、亚细胞结构、动态状态三类数据支柱 → 细胞复杂性分解为八个功能模块（遗传、代谢、结构系统），各模块为领域AI工具并由大语言模型调度层协调

最近 5 个完整年度引用趋势