洞察前沿，连接科研新知

完整作者

Nicolás Gómez-Banoy、Jorge A Barrero、Luiza Rachel Pinheiro de Carvalho、Caroline S Jiang、Tara Doma Lama、Nakul Karandikar、Mascha Koenen、Tiffany Lam、Kaja Plucińska、Ksenia Morozova、Stephanie Chahwan、Gustavo Barraza、Burcin Agridag Ucpinar、Jennifer E Liu、Rohit Sharma、Daniel Lafontaine、Heiko Schöder、Paul Cohen

作者机构

• Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.
• Department of Medicine, Division of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Weill Cornell Medicine, New York, NY, USA.
• Departamento de Ciencias Fisiológicas, Laboratorio de Lípidos y Diabetes, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia.
• Center for Clinical and Translational Science, The Rockefeller University, New York, NY, USA.
• Metabolic Phenotyping Center, Core Laboratories Center, Weill Cornell Medicine, New York, NY, USA.
• Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
• Laboratory of Tissue Dynamics and Organ Crosstalk, Helmholtz Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association at Heidelberg University, Mannheim, Germany.
• Department of Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.
• Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Department of Medicine, Cardiology Service, Memorial Sloan Kettering Cancer Center/Weill Cornell Medicine, New York, NY, USA.
• Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA. pcohen@rockefeller.edu.

技术路线

大数据队列（101,243例患者） → 无偏分析及机器学习半自动量化BAT活性（约8,700例）

最近 5 个完整年度引用趋势

完整作者

MacLean C Sellars、Jessica A Frank、Bohoon Shim、Allison Vanasse、Ruolin Liu、Cleo Forman、Chloe R Tu、Kyohei K Tabata、Antonia Kowelewski、Su-Chun Cheng、Catherine Song、Kan Xiong、Pia Jain、Andjela Crnjac、Haley E Sax、Vipheaviny Chea、Wesley Lu、J Thomas Janes、Micah Rickles-Young、Amit Sud、Savni Sarolkar、Martin Hayes、Oriol Olive、Haley Greenslade、Carrie Cibulskis、Nir Hacohen、Edward F Fritsch、Shuqiang Li、Kenneth J Livak、Nabihah Tayob、Elizabeth H Stover、Carolyn Krasner、Rebecca Porter、Ursula Matulonis、Gad Getz、Giacomo Oliveira、Patrick A Ott、Jeremy M Simon、Viktor A Adalsteinsson、Derin B Keskin、Panagiotis A Konstantinopoulos、Catherine J Wu

作者机构

• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• Harvard Medical School, Boston, MA, USA.
• Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
• Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
• Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
• Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
• Department of Pathology, Harvard Medical School, Boston, MA, USA.
• Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
• Department of Medical Education and Biomedical Sciences, Methodist University CFVH School of Medicine, Fayetteville, NC, USA.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Harvard Medical School, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Mellen and Eisenson Family Center for BRCA and Related Genes, Dana-Farber Cancer Institute, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Harvard Medical School, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.

技术路线

肿瘤样本/诊断活检 → 个体化新抗原筛选与合成多肽库（NeoVax）制备

最近 5 个完整年度引用趋势

完整作者

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完整作者

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完整作者

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完整作者

Ahmed Reda Bahr、Youssef Basem、Amani Alhejely、Abdel Rahman Alaa、Saifallah Mabrouk Abozeid、Amira Basem、Mohsen A Khormi、Mabrouk A Abo-Zaid

作者机构

• Faculty of Medicine, Alexandria University, Alexandria, Egypt.
• Medical and Pharmaceutical Industrial Biotechnology Department, College of Biotechnology, Misr University for Science and Technology (MUST), Giza, Egypt.
• Biology Department, Darb University College, Jazan University, Jazan, Saudi Arabia.
• Faculty of Medicine, Cairo University, Kasr AlAiny, Egypt.
• Department of Biotechnology and Genetic Engineering, College of Science, Helwan National University, Cairo, Egypt.
• Department of Biology, College of Science, Jazan University, Jazan, Saudi Arabia.

技术路线

暂未整理

最近 5 个完整年度引用趋势

完整作者

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最近 5 个完整年度引用趋势

完整作者

Venise Jan Castillon、Amy X Xie、Sonia Boscenco、Ethan Tse、Neil Ruthen、Jamie Wang、Ziad Bakouny、Michele Waters、Chenlian Fu、Christopher Fong、Mustafa Saleh、Tarek Baroud、Wungki Park、Urvi A Shah、A Ari Hakimi、Puneeth Iyengar、Justin Jee、Eileen White、Alexander Gusev、Tobias Janowitz、Marcus D Goncalves、Ed Reznik

作者机构

• Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Dana-Farber Cancer Institute, Boston, MA, USA.
• Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Weill Cornell Medical College, New York, NY, USA.
• Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Rutgers Cancer Institute, Rutgers University, New Brunswick, NJ, USA.
• Ludwig Princeton Branch, Ludwig Institute for Cancer Research, Princeton University, Princeton, NJ, USA.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Harvard Medical School, Boston, MA, USA.
• Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
• Northwell Health Cancer Institute, Northwell Health, New Hyde Park, NY, USA.
• Holman Division of Endocrinology, Diabetes & Metabolism, Department of Medicine and Radiation Oncology, NYU Langone Health, New York, NY, USA.
• Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. reznike@mskcc.org.

技术路线

纵向临床基因组数据（MSK-IMPACT，52,236例患者，2010-2024）→定义共识性恶病质体重减轻的发作分辨轨迹并关联结局、血清学与肿瘤基因型→多变量模型预测肺癌、结直肠癌和前列腺癌的恶病质体重减轻风险→在Dana-Farber癌症研究所独立外部队列（n=5,785）中验证

最近 5 个完整年度引用趋势