洞察前沿，连接科研新知

完整作者

Le Yuan、Jianan Canal Li、Miaoyuan Wen、David M Bianchi、Katherine Arneson、Bingji Guo、Sara Lambert、Chris Stephens、Tianhao Yu、Lijiang Fu、Christopher Pond、Matthew J Berry、Huimin Zhao

作者机构

• Department of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.
• Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.
• NSF Molecule Maker Lab Institute, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.
• Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, CA 94720, United States.
• School of Information Sciences, University of Illinois Urbana-Champaign, Champaign, IL 61820, United States.
• National Center for Supercomputing Applications, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.
• NSF iBioFoundry, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.
• NSF Global Center for Biofoundry Applications, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States.

技术路线

数据/样本：汇总1,098,305株菌株的蛋白序列，由CLEAN AI模型预测获得>5500万条酶功能注释；分析：通过网页界面提供灵活查询的检索、浏览与下载功能，并以蛋白语言模型支持突变效应预测，结果以交互热图、结构叠合和表格可视化展示；验证：原文未报告对预测注释或突变效应预测的实验验证。

最近 5 个完整年度引用趋势

完整作者

Wanxin Cao、Bin Jiang、Xiangyin Chi、Wan Li、Hong Yang、Xiaoxue Li、Yuxuan Zhao、Xu Zhang、Rui Meng、Yanyu Cang、Guanhua Du、Jinhua Wang

作者机构

• Beijing Key Laboratory of Innovative Drug Discovery and Polymorphic Druggability Research for Cerebrovascular Diseases, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
• School of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang 117004, China.
• School of Pharmacy, Henan University, Kaifeng 475004, China.
• Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China.

技术路线

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最近 5 个完整年度引用趋势

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完整作者

MacLean C Sellars、Jessica A Frank、Bohoon Shim、Allison Vanasse、Ruolin Liu、Cleo Forman、Chloe R Tu、Kyohei K Tabata、Antonia Kowelewski、Su-Chun Cheng、Catherine Song、Kan Xiong、Pia Jain、Andjela Crnjac、Haley E Sax、Vipheaviny Chea、Wesley Lu、J Thomas Janes、Micah Rickles-Young、Amit Sud、Savni Sarolkar、Martin Hayes、Oriol Olive、Haley Greenslade、Carrie Cibulskis、Nir Hacohen、Edward F Fritsch、Shuqiang Li、Kenneth J Livak、Nabihah Tayob、Elizabeth H Stover、Carolyn Krasner、Rebecca Porter、Ursula Matulonis、Gad Getz、Giacomo Oliveira、Patrick A Ott、Jeremy M Simon、Viktor A Adalsteinsson、Derin B Keskin、Panagiotis A Konstantinopoulos、Catherine J Wu

作者机构

• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• Harvard Medical School, Boston, MA, USA.
• Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
• Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
• Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
• Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
• Department of Pathology, Harvard Medical School, Boston, MA, USA.
• Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
• Department of Medical Education and Biomedical Sciences, Methodist University CFVH School of Medicine, Fayetteville, NC, USA.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Harvard Medical School, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Mellen and Eisenson Family Center for BRCA and Related Genes, Dana-Farber Cancer Institute, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Harvard Medical School, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.

技术路线

肿瘤样本/诊断活检 → 个体化新抗原筛选与合成多肽库（NeoVax）制备

最近 5 个完整年度引用趋势

完整作者

Hojae Choi、Magnus S Bauer、Brian Coventry、Preetham Venkatesh、Anqi Chen、Donghyo Kim、Asim K Bera、Alex Kang、Hannah Nguyen、Shayan Sadre、Justin Decarreau、Emily Joyce、Bhanumathi Shankaran、Tuscan Rock Thompson、Gabriel Greenstein、Kieran Didi、Lars L Schaaf、Jacob Merle Gershon、Alexander F Shida、Gyu Rie Lee、Donald Hilvert、Samuel J Pellock、David Baker

作者机构

• Department of Biochemistry, University of Washington, Seattle, WA, USA.
• Institute for Protein Design, University of Washington, Seattle, WA, USA.
• Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA.
• Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
• Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA.
• Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
• Department of Materials Science & Engineering, Stanford University, Stanford, CA, USA.
• Department of Computer Science, University of Oxford, Oxford, UK.
• NVIDIA, Santa Clara, CA, USA.
• Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, UK.
• Department of Materials, Imperial College London, London, UK.
• Department of Molecular Engineering, University of Washington, Seattle, WA, USA.
• Medical Scientist Training Program, University of Washington, Seattle, WA, USA.
• Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
• Laboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland. hilvert@ethz.ch.
• Department of Biochemistry, University of Washington, Seattle, WA, USA. spellock@uw.edu.
• Institute for Protein Design, University of Washington, Seattle, WA, USA. spellock@uw.edu.
• Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
• Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
• Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu.

技术路线

设计模型与实验结构（6个晶体结构） → 序列依赖性水解活性分析（kcat/kuncat、成功率13/69）

最近 5 个完整年度引用趋势

完整作者

Hua Wu、Yanyan Hu、Hanzhi Yu、Nana Huang、Lu Shi、Menghan Gao、Xinghan Du、Xue Lu、Yuxia Zhang、Xiya Sun、Xiaoqing Xu、Zhimin Liu、Junsong Yuan、Wei Zhou、Qiliang Shao、Dan Wang、Yangyu Zhao、Tianhua Ma、Sheng Ding

作者机构

• New Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
• Howard Hughes Medical Institute, Chevy Chase, MD, USA.
• Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
• Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
• National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.
• National Center for Healthcare Quality Management in Obstetrics, Beijing, China.
• State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
• Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
• CRE Life Institute, Beijing, China.
• Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
• New Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China. matianhua@tsinghua.edu.cn.
• New Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China. shengding@tsinghua.edu.cn.
• Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China. shengding@tsinghua.edu.cn.

技术路线

化学诱导全能样干细胞(ciTotiSCs) → 自组织形成类囊胚结构

最近 5 个完整年度引用趋势

完整作者

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