Vincent J Straub、Stefania Benonisdottir、Giovanni Scotti Bentivoglio、Neil Wary、Robert Campbell、Augustine Kong、Melinda C Mills
作者机构
Leverhulme Centre for Demographic Science, Nuffield Department of Population Health, University of Oxford and Nuffield College, Oxford, UK. vincent.straub@ndph.ox.ac.uk.
Leverhulme Centre for Demographic Science, Nuffield Department of Population Health, University of Oxford and Nuffield College, Oxford, UK.
Institute of Physical Sciences, University of Iceland, Reykjavík, Iceland.
Department of Economics, Econometrics and Finance, University of Groningen, Groningen, the Netherlands.
Leverhulme Centre for Demographic Science, Nuffield Department of Population Health, University of Oxford and Nuffield College, Oxford, UK. melinda.mills@demography.ox.ac.uk.
Department of Economics, Econometrics and Finance, University of Groningen, Groningen, the Netherlands. melinda.mills@demography.ox.ac.uk.
Department of Genetics, University Medical Centre Groningen, Groningen, the Netherlands. melinda.mills@demography.ox.ac.uk.
Comparative proteomics of human anterior lens capsules reveals ATP6V1A-associated lysosomal dysregulation in age-related cataract with primary angle-closure glaucoma.
Sian Liu、Wenxin Zheng、Jin Kang、Tianyi Xu、Siming Chen、Gen Li、Junlong Li、Hang Wong、Meihao Wang、Xiaokai Bai、Changxi Hu、Cheng Tang、Shengwei Jin、Zixing Zou、Ieng Chong、Yuxing Lu、Io Nam Wong、Hui Xu、Charlotte L Zhang、Jingman Shi、Erhu Feng、Jinyu Gu、Zhuo Sun、Haibo Chen、Li Yang、Yuan Zhang、Xian Zhu、Huanhuan Huang、Xiuyuan Xu、Xue Li、Zhenhui Zhao、Hongbo Qi、Xinyu Lu、Ngaman Cheng、Sicheng Pan、Ning Sun、Yun Yin、Michelle Williams、Eric Oermann、John E J Rasko、Jin Li、Kai Wang、Kang Zhang、Hao Wu、Yubin Xia、Fanxin Zeng、International Consortium of Digital Twins in Healthcare and Medicine
作者机构
Center for Big Data and Intelligent Medicine, The First Affiliated Hospital of Chongqing Medical University; Key Laboratory of Digital Health and Intelligent Medicine, Chongqing Municipal Health Commission and Chongqing Translational Medicine Center, Chongqing, China.
State Key Lab of Eye Health and Clinical Data Science Institute, Institute for Advanced Study on Eye Health and Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Department of Computer Science, Shanghai Jiao Tong University, Shanghai, China.
Artificial Intelligence Cross Disciplinary Research Institute and Faculty of Medicine, Macau University of Science and Technology, Macau, China.
Department of Radiology, Department of Anesthesia and Critical Care, Key Laboratory of Pediatric Anesthesiology, Ministry of Education, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, China.
Guangzhou National Laboratory, Guangzhou, China.
Department of Big Data and Biomedical AI, College of Future Technology, Peking University, Beijing, China.
College of Computer Science, Sichuan University, Chengdu, China.
Department of Clinical Research Center, Dazhou Central Hospital and Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Dazhou, China.
Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Baichuan Inc., Beijing, China.
Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, USA.
Departments of Neurosurgery, Radiology and Data Science, Neuroscience Institute, NYU Langone Medical Center, New York University, New York, NY, USA.
Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.
College of Life Science, Fudan University, Shanghai, China. li_jin_lifescience@fudan.edu.cn.
Artificial Intelligence Cross Disciplinary Research Institute and Faculty of Medicine, Macau University of Science and Technology, Macau, China. kaiwang314@gmail.com.
State Key Lab of Eye Health and Clinical Data Science Institute, Institute for Advanced Study on Eye Health and Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China. kang.zhang@gmail.com.
Artificial Intelligence Cross Disciplinary Research Institute and Faculty of Medicine, Macau University of Science and Technology, Macau, China. kang.zhang@gmail.com.
Guangzhou National Laboratory, Guangzhou, China. kang.zhang@gmail.com.
Center for Big Data and Intelligent Medicine, The First Affiliated Hospital of Chongqing Medical University; Key Laboratory of Digital Health and Intelligent Medicine, Chongqing Municipal Health Commission and Chongqing Translational Medicine Center, Chongqing, China. wuhao@cqmu.edu.cn.
Department of Computer Science, Shanghai Jiao Tong University, Shanghai, China. xiayubin@sjtu.edu.cn.
Department of Clinical Research Center, Dazhou Central Hospital and Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Dazhou, China. zengfx@pku.edu.cn.
Philip M Croon、Bruno Batinica、Lovedeep S Dhingra、Ryan B Choi、Evangelos K Oikonomou、Sumukh V Shankar、Veer Sangha、Robert M A van der Boon、Michelle Michels、Maarten van Ettinger、Peter-Paul Zwetsloot、Sergio Teruya、Cesia Gallegos Kattan、Edward J Miller、Navid Noory、Oscar M Westin、Sie K Fensman、Steen Hvitfeldt Poulsen、Avneet Singh、Sudarshan Balla、Anouk Achten、Charalambos Vlachopoulos、Alexios S Antonopoulos、Nico Bruining、Julian D Gillmore、Mathew S Maurer、Frederick L Ruberg、Marianna Fontana、Rohan Khera
作者机构
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Cardiovascular Data Science (CarDS) Lab, Yale School of Medicine, New Haven, Connecticut.
Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Thoraxcenter, Cardiovascular Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Division of Cardiology, Columbia University Irving Medical Center, New York, New York.
Heart Center, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Department of Cardiology, Northwell Health, New York, New York.
Department of Cardiology, West Virginia University Heart and Vascular Institute, Morgantown.
Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, the Netherlands.
National Amyloidosis Centre, University College London, Royal Free Hospital, London, United Kingdom.
Cardiogenetics Unit, First Department of Cardiology, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Greece.
Section of Cardiovascular Medicine and Amyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, Massachusetts.
Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connecticut.
Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, Connecticut.
Section of Health Informatics, Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut.
Fei Liu、Kai Wang、Hui Xu、Cheng Tang、Xian Shen、Meihao Wang、Lei Yang、Li Yang、Li Liu、Changxi Hu、Gen Li、Wei Wu、Zixing Zou、Bingzhou Li、Sian Liu、Jin Kang、Jungho Kong、Ting Li、Io Nam Wong、Xiaoying Huang、Gang Chen、Wenyang Lu、Ian Ziyar、Charlotte L Zhang、Yiwen Sun、Weihong Lin、Caiwen Ou、Manson Fok、Taiwa Hou、Winston Wang、Kanmin Xue、Yun Yin、Hao Zhu、Jonathan Gootenberg、Omar O Abudayyeh、Michael Karin、Alexandre Loupy、John E J Rasko、Trey Ideker、Huiyan Luo、Eric Oermann、Kang Zhang、International Consortium of Digital Twins in Healthcare and Medicine
作者机构
Clinical Data Science Institute, State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, and The Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; Department of Urology, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China; Guangzhou National Laboratory, Guangzhou, China.
Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Clinical Data Science Institute, State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, and The Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Clinical Data Science Institute, State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, and The Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; Department of General Surgery, Department of Hepatobiliary Surgery, Zhejiang-Germany Interdisciplinary Joint Laboratory of Hepatobiliary-Pancreatic Tumor and Bioengineering, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Radiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Intelligent Medical Imaging of Wenzhou, Healthcare Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Orthopedics, Key Laboratory of Hepatosplenic Surgery of Ministry of Education, the First Affiliated Hospital, Harbin Medical University, Harbin, China.
Department of Respiratory and Critical Care Medicine, Center for Big Data and Intelligent Medicine, the First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Digital Health and Intelligent Medicine, Chongqing Municipal Health Commission, Chongqing Translational Medicine Center, Chongqing, China.
Department of Health Management, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Big Data and Biomedical AI, College of Future Technology, Peking University, Peking-Tsinghua Center for Life Sciences, Beijing, China.
Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China; Guangzhou National Laboratory, Guangzhou, China.
Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China.
Departments of Medicine and Bioengineering, Moores Cancer Center, School of Medicine, UC San Diego, CA, USA.
Division of Pulmonary Medicine, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou Key Laboratory of Interdisciplinary and Translational Medicine, Wenzhou Key Laboratory of Heart and Lung, Wenzhou, Zhejiang, China.
Nepean Hospital, Sydney, Australia.
Key Laboratory of Intelligent Medical Imaging of Wenzhou, Healthcare Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Dongguan Hospital, Southern Medical University, Guangzhou, China.
Conde S. Januario Hospital, Macau, China.
Department of Internal Medicine, Mayo Clinic, Arizona, USA.
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Clinical Data Science Institute, State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, and The Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; Faculty of Health and Wellness, Faculty of Business, City University of Macau, Taipa, Macau SAR, China.
Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.
Université Paris Cité, INSERM U970 PARCC, Paris Institute for Transplantation and Organ Regeneration, F-75015 Paris, France; Department of Kidney Transplantation, Assistance Publique - Hôpitaux de Paris, Paris, France.
Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.
Departments of Medicine and Bioengineering, Moores Cancer Center, School of Medicine, UC San Diego, CA, USA; Big Data Institute, Oxford University, Oxford, UK.
Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.
Departments of Neurosurgery, Radiology, and Data Science, Neuroscience Institute, NYU Langone Medical Center, New York University, New York, NY, USA.
Clinical Data Science Institute, State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, and The Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China; Guangzhou National Laboratory, Guangzhou, China; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China. Electronic address: kang.zhang@gmail.com.
技术路线
3.67 million individuals/17.7 million clinical visits (COMPASS cohort, longitudinal EHR + chest X-ray) → Oncoformer unified multimodal transformer analysis → validation on independent external cohorts including UK Biobank, with staging independently validated against postoperative pathological endpoints and convergence on core cancer genomic pathways
Ximing Ran、Joanne Wuu、Zhaohui S Qin、Michael P McDermott、Johnathan Cooper-Knock、Yindi Li、Volkan Granit、Anne-Laure Grignon、Elizabeth Lin、Maria Catalina Fernandez、Danielle Colato、Nathan Carberry、Christina M Lill、Paolo Piazza、Andrea Malaspina、Michael Benatar
作者机构
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
Department of Computer Science, Emory University, Atlanta, GA, USA.
Department of Neurology and ALS Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
NIHR Sheffield Biomedical Research Centre, Sheffield, UK.
Department of Neuromuscular Diseases, UCL Queen Square Motor Neuron Disease Center, UCL Queen Square Institute of Neurology, University College London, London, UK.
Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Ageing and Epidemiology Unit (AGE), School of Public Health, Imperial College London, London, UK.
Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.
Department of Neurology and ALS Center, University of Miami Miller School of Medicine, Miami, FL, USA. mbenatar@med.miami.edu.
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