洞察前沿，连接科研新知

完整作者

Nicolás Gómez-Banoy、Jorge A Barrero、Luiza Rachel Pinheiro de Carvalho、Caroline S Jiang、Tara Doma Lama、Nakul Karandikar、Mascha Koenen、Tiffany Lam、Kaja Plucińska、Ksenia Morozova、Stephanie Chahwan、Gustavo Barraza、Burcin Agridag Ucpinar、Jennifer E Liu、Rohit Sharma、Daniel Lafontaine、Heiko Schöder、Paul Cohen

作者机构

• Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA.
• Department of Medicine, Division of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Weill Cornell Medicine, New York, NY, USA.
• Departamento de Ciencias Fisiológicas, Laboratorio de Lípidos y Diabetes, Facultad de Medicina, Universidad Nacional de Colombia, Bogota, Colombia.
• Center for Clinical and Translational Science, The Rockefeller University, New York, NY, USA.
• Metabolic Phenotyping Center, Core Laboratories Center, Weill Cornell Medicine, New York, NY, USA.
• Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA.
• Laboratory of Tissue Dynamics and Organ Crosstalk, Helmholtz Institute for Translational AngioCardioScience (HI-TAC) of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association at Heidelberg University, Mannheim, Germany.
• Department of Medicine, Weill Cornell Medicine/New York Presbyterian Hospital, New York, NY, USA.
• Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Department of Medicine, Cardiology Service, Memorial Sloan Kettering Cancer Center/Weill Cornell Medicine, New York, NY, USA.
• Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
• Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA. pcohen@rockefeller.edu.

技术路线

大数据队列（101,243例患者） → 无偏分析及机器学习半自动量化BAT活性（约8,700例）

最近 5 个完整年度引用趋势

完整作者

MacLean C Sellars、Jessica A Frank、Bohoon Shim、Allison Vanasse、Ruolin Liu、Cleo Forman、Chloe R Tu、Kyohei K Tabata、Antonia Kowelewski、Su-Chun Cheng、Catherine Song、Kan Xiong、Pia Jain、Andjela Crnjac、Haley E Sax、Vipheaviny Chea、Wesley Lu、J Thomas Janes、Micah Rickles-Young、Amit Sud、Savni Sarolkar、Martin Hayes、Oriol Olive、Haley Greenslade、Carrie Cibulskis、Nir Hacohen、Edward F Fritsch、Shuqiang Li、Kenneth J Livak、Nabihah Tayob、Elizabeth H Stover、Carolyn Krasner、Rebecca Porter、Ursula Matulonis、Gad Getz、Giacomo Oliveira、Patrick A Ott、Jeremy M Simon、Viktor A Adalsteinsson、Derin B Keskin、Panagiotis A Konstantinopoulos、Catherine J Wu

作者机构

• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• Harvard Medical School, Boston, MA, USA.
• Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
• Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA.
• Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
• Krantz Family Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
• Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
• Department of Pathology, Harvard Medical School, Boston, MA, USA.
• Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
• Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
• Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
• Department of Medical Education and Biomedical Sciences, Methodist University CFVH School of Medicine, Fayetteville, NC, USA.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Harvard Medical School, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Mellen and Eisenson Family Center for BRCA and Related Genes, Dana-Farber Cancer Institute, Boston, MA, USA. Panogiotis_Konstantinopoulos@dfci.harvard.edu.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Harvard Medical School, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Broad Institute of MIT and Harvard, Cambridge, MA, USA. Catherine_Wu@dfci.harvard.edu.
• Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Catherine_Wu@dfci.harvard.edu.

技术路线

肿瘤样本/诊断活检 → 个体化新抗原筛选与合成多肽库（NeoVax）制备

最近 5 个完整年度引用趋势

完整作者

Hojae Choi、Magnus S Bauer、Brian Coventry、Preetham Venkatesh、Anqi Chen、Donghyo Kim、Asim K Bera、Alex Kang、Hannah Nguyen、Shayan Sadre、Justin Decarreau、Emily Joyce、Bhanumathi Shankaran、Tuscan Rock Thompson、Gabriel Greenstein、Kieran Didi、Lars L Schaaf、Jacob Merle Gershon、Alexander F Shida、Gyu Rie Lee、Donald Hilvert、Samuel J Pellock、David Baker

作者机构

• Department of Biochemistry, University of Washington, Seattle, WA, USA.
• Institute for Protein Design, University of Washington, Seattle, WA, USA.
• Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA.
• Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
• Molecular and Cellular Biology Program, University of Washington, Seattle, WA, USA.
• Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
• Department of Materials Science & Engineering, Stanford University, Stanford, CA, USA.
• Department of Computer Science, University of Oxford, Oxford, UK.
• NVIDIA, Santa Clara, CA, USA.
• Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, UK.
• Department of Materials, Imperial College London, London, UK.
• Department of Molecular Engineering, University of Washington, Seattle, WA, USA.
• Medical Scientist Training Program, University of Washington, Seattle, WA, USA.
• Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
• Laboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland. hilvert@ethz.ch.
• Department of Biochemistry, University of Washington, Seattle, WA, USA. spellock@uw.edu.
• Institute for Protein Design, University of Washington, Seattle, WA, USA. spellock@uw.edu.
• Department of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
• Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.
• Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA. dabaker@uw.edu.

技术路线

设计模型与实验结构（6个晶体结构） → 序列依赖性水解活性分析（kcat/kuncat、成功率13/69）

最近 5 个完整年度引用趋势

完整作者

Hua Wu、Yanyan Hu、Hanzhi Yu、Nana Huang、Lu Shi、Menghan Gao、Xinghan Du、Xue Lu、Yuxia Zhang、Xiya Sun、Xiaoqing Xu、Zhimin Liu、Junsong Yuan、Wei Zhou、Qiliang Shao、Dan Wang、Yangyu Zhao、Tianhua Ma、Sheng Ding

作者机构

• New Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
• Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
• Howard Hughes Medical Institute, Chevy Chase, MD, USA.
• Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China.
• Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
• National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital), Beijing, China.
• National Center for Healthcare Quality Management in Obstetrics, Beijing, China.
• State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
• Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.
• CRE Life Institute, Beijing, China.
• Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
• New Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China. matianhua@tsinghua.edu.cn.
• New Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China. shengding@tsinghua.edu.cn.
• Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China. shengding@tsinghua.edu.cn.

技术路线

化学诱导全能样干细胞(ciTotiSCs) → 自组织形成类囊胚结构

最近 5 个完整年度引用趋势

完整作者

暂未整理

作者机构

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技术路线

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最近 5 个完整年度引用趋势

暂无引用数据

完整作者

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技术路线

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最近 5 个完整年度引用趋势

完整作者

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技术路线

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最近 5 个完整年度引用趋势

完整作者

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技术路线

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最近 5 个完整年度引用趋势

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完整作者

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技术路线

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最近 5 个完整年度引用趋势

暂无引用数据

完整作者

Ahmed Reda Bahr、Youssef Basem、Amani Alhejely、Abdel Rahman Alaa、Saifallah Mabrouk Abozeid、Amira Basem、Mohsen A Khormi、Mabrouk A Abo-Zaid

作者机构

• Faculty of Medicine, Alexandria University, Alexandria, Egypt.
• Medical and Pharmaceutical Industrial Biotechnology Department, College of Biotechnology, Misr University for Science and Technology (MUST), Giza, Egypt.
• Biology Department, Darb University College, Jazan University, Jazan, Saudi Arabia.
• Faculty of Medicine, Cairo University, Kasr AlAiny, Egypt.
• Department of Biotechnology and Genetic Engineering, College of Science, Helwan National University, Cairo, Egypt.
• Department of Biology, College of Science, Jazan University, Jazan, Saudi Arabia.

技术路线

暂未整理

最近 5 个完整年度引用趋势