State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.
State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China. mukvince@sjtu.edu.cn.
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China. liqian2018@sjtu.edu.cn.
State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.
Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Hebei Senlang Biotechnology, Shijiazhuang, China.
Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. dr_wangli@126.com.
State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China. hjdou@sjtu.edu.cn.
Shengxin Zhang、Keqin Tan、Qin Zhang、Yuzhe Zhao、Ziyang Cheng、Xinggang Yang、Jingsi Dong、Jiaming Liu、Xuelei Ma
作者机构
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Postgraduate Students, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Department of Hematology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Respiratory and Critical Care Medicine, Institute of Respiratory Health, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.
Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan, China. dongjingsi@wchscu.edu.cn.
Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China. dongjingsi@wchscu.edu.cn.
Department of Urology, West China Hospital, Sichuan University, Chengdu, China. JM3099@163.com.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China. maxuelei0726@wchscu.cn.
Fei Liu、Kai Wang、Hui Xu、Cheng Tang、Xian Shen、Meihao Wang、Lei Yang、Li Yang、Li Liu、Changxi Hu、Gen Li、Wei Wu、Zixing Zou、Bingzhou Li、Sian Liu、Jin Kang、Jungho Kong、Ting Li、Io Nam Wong、Xiaoying Huang、Gang Chen、Wenyang Lu、Ian Ziyar、Charlotte L Zhang、Yiwen Sun、Weihong Lin、Caiwen Ou、Manson Fok、Taiwa Hou、Winston Wang、Kanmin Xue、Yun Yin、Hao Zhu、Jonathan Gootenberg、Omar O Abudayyeh、Michael Karin、Alexandre Loupy、John E J Rasko、Trey Ideker、Huiyan Luo、Eric Oermann、Kang Zhang、International Consortium of Digital Twins in Healthcare and Medicine
作者机构
Clinical Data Science Institute, State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, and The Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; Department of Urology, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China; Guangzhou National Laboratory, Guangzhou, China.
Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Clinical Data Science Institute, State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, and The Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Clinical Data Science Institute, State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, and The Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; Department of General Surgery, Department of Hepatobiliary Surgery, Zhejiang-Germany Interdisciplinary Joint Laboratory of Hepatobiliary-Pancreatic Tumor and Bioengineering, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Radiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; Key Laboratory of Intelligent Medical Imaging of Wenzhou, Healthcare Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Orthopedics, Key Laboratory of Hepatosplenic Surgery of Ministry of Education, the First Affiliated Hospital, Harbin Medical University, Harbin, China.
Department of Respiratory and Critical Care Medicine, Center for Big Data and Intelligent Medicine, the First Affiliated Hospital of Chongqing Medical University, Key Laboratory of Digital Health and Intelligent Medicine, Chongqing Municipal Health Commission, Chongqing Translational Medicine Center, Chongqing, China.
Department of Health Management, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Big Data and Biomedical AI, College of Future Technology, Peking University, Peking-Tsinghua Center for Life Sciences, Beijing, China.
Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China; Guangzhou National Laboratory, Guangzhou, China.
Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China.
Departments of Medicine and Bioengineering, Moores Cancer Center, School of Medicine, UC San Diego, CA, USA.
Division of Pulmonary Medicine, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou Key Laboratory of Interdisciplinary and Translational Medicine, Wenzhou Key Laboratory of Heart and Lung, Wenzhou, Zhejiang, China.
Nepean Hospital, Sydney, Australia.
Key Laboratory of Intelligent Medical Imaging of Wenzhou, Healthcare Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Dongguan Hospital, Southern Medical University, Guangzhou, China.
Conde S. Januario Hospital, Macau, China.
Department of Internal Medicine, Mayo Clinic, Arizona, USA.
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Clinical Data Science Institute, State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, and The Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; Faculty of Health and Wellness, Faculty of Business, City University of Macau, Taipa, Macau SAR, China.
Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Gene and Cell Therapy Institute, Mass General Brigham, Cambridge, MA, USA.
Université Paris Cité, INSERM U970 PARCC, Paris Institute for Transplantation and Organ Regeneration, F-75015 Paris, France; Department of Kidney Transplantation, Assistance Publique - Hôpitaux de Paris, Paris, France.
Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China; Biomedical Pioneering Innovation Center (BIOPIC), School of Life Sciences, Peking University, Beijing, China.
Departments of Medicine and Bioengineering, Moores Cancer Center, School of Medicine, UC San Diego, CA, USA; Big Data Institute, Oxford University, Oxford, UK.
Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou, China.
Departments of Neurosurgery, Radiology, and Data Science, Neuroscience Institute, NYU Langone Medical Center, New York University, New York, NY, USA.
Clinical Data Science Institute, State Key Laboratory of Macromolecular Drugs and Large-scale Manufacturing, and The Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China; Artificial Intelligence Cross Disciplinary Research Institute, Faculty of Medicine, Macau University of Science and Technology, Macau, China; Guangzhou National Laboratory, Guangzhou, China; State Key Laboratory of Eye Health, Eye Hospital, Wenzhou Medical University, Wenzhou, China. Electronic address: kang.zhang@gmail.com.
技术路线
3.67 million individuals/17.7 million clinical visits (COMPASS cohort, longitudinal EHR + chest X-ray) → Oncoformer unified multimodal transformer analysis → validation on independent external cohorts including UK Biobank, with staging independently validated against postoperative pathological endpoints and convergence on core cancer genomic pathways
Ximing Ran、Joanne Wuu、Zhaohui S Qin、Michael P McDermott、Johnathan Cooper-Knock、Yindi Li、Volkan Granit、Anne-Laure Grignon、Elizabeth Lin、Maria Catalina Fernandez、Danielle Colato、Nathan Carberry、Christina M Lill、Paolo Piazza、Andrea Malaspina、Michael Benatar
作者机构
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA.
Department of Computer Science, Emory University, Atlanta, GA, USA.
Department of Neurology and ALS Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
NIHR Sheffield Biomedical Research Centre, Sheffield, UK.
Department of Neuromuscular Diseases, UCL Queen Square Motor Neuron Disease Center, UCL Queen Square Institute of Neurology, University College London, London, UK.
Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Ageing and Epidemiology Unit (AGE), School of Public Health, Imperial College London, London, UK.
Nuffield Department of Medicine, Centre for Human Genetics, University of Oxford, Oxford, UK.
Department of Neurology and ALS Center, University of Miami Miller School of Medicine, Miami, FL, USA. mbenatar@med.miami.edu.
Mathieu Rouanne、Noah Chen、Dylan L Mariuzza、Zaofeng Yang、Fangda Li、Kenia de Los Santos-Alexis、Thomas M Savage、Rosa L Vincent、Cathy L Mendelsohn、Tal Danino、Nicholas Arpaia
作者机构
Department of Microbiology & Immunology, Columbia University, New York, NY 10032, USA.
Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA.
Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Department of Urology, Columbia University, New York, NY 10032, USA.
Data Science Institute, Columbia University, New York, NY 10027, USA.
为什么值得关注
编辑短评该文针对现有生化与合成材料方法难以动态调控细胞间相互作用力学的问题，构建kpiCells仿生人工细胞平台，模拟细胞状态并参与生理性相互作用。其价值在于将机械、化学与形貌输入模块化整合，为解码免疫突触机械调控提供可控实验体系。